Isn't the child's height short, will the child grow taller?Experts tell you the answer

Author:Hunan Medical Chat Time:2022.09.03

"Director Tan, you can help see, the child and my dad are not short. Why is my cubs growing up from a young age? I also took him a lot of inspections, but I didn't find out where the problem was!"

"Actually, a large part of children with short height and shorter are unknown. At this time, only conventional testing often cannot find the cause. It is recommended that you can do a genetic testing and screening."

Do parents not be short when they are not short?

In June of this year, Director Tan Chuanmei, a pediatric security department of Hunan Women's and Children's Hospital, ushered in a 3 -year -old boy Hao Hao (a pseudonym). Like other children, Hao Hao was also brought to the height of his parents, but the consultation During the process, Director Tan found that Hao Hao was actually different from other ordinary short patients.

During the consultation, Hao Hao's mother told Director Tan that the child was born in 40 weeks and was born with only 2.6kg (

(Note: Male and female newborns, the calculation of fetal age calculation ≤p10 is "less than the fetal age")

In addition, Director Tan Chuanmei also learned that Hao Hao's father's height was 179cm, her mother was 159cm, and Hao Hao's height (can evaluate growth potential) can reach 175.5 ± 5cm. However, after finishing a physical examination for Hao Hao, Director Tan found that Hao Hao, who is now 3 years and 8 months old, is only 96.5cm tall, weighs 13.2kg, and has an average height difference between the same age and a height difference of 6cm.

During the face -to -face diagnosis, Director Tan Chuanmei found that Hao Hao's hairline was low during physical examination, the nose bridge was sunken, his nose was short, his nostrils leaned forward, and he was accompanied by neck, humpback, and passing the palm, but his intelligence was normal, but his intelligence was normal. Essence With years of clinical experience, Director Tan Chuanmei noticed that Hao Hao was not a common ordinary dwarf. It was suggested that parents do a systematic comprehensive examination for their children, including genetic testing.

It is the key to find a problem to find a problem in a timely manner in time.

Hao Hao's genetic test results prompt C.52G> A (P.ASP18ASN) mutation into the wrong meaning mutation of the POU1F1 gene encoding area, which means that Hao Hao has a genetic mutation when he is still in his mother's belly, which has led him to him is that he is "Smaller than fetal age" also further explains why Hao Hao has not been long over the years.

Director Tan Chuanmei also told his parents that in the growth and development of children, it will be adjusted and controlled by various factors. Individual growth and ultimate height are the result of genetic and weight, body length, nutrition, and endocrine hormones during birth. Among the above many factors, the secretion of growth hormone plays a very important role in the impact of height.

At present, the reason for Hao Hao's short height has been found. Next, customized systematic treatment is performed. As soon as possible, the child's adult height can still be improved significantly.

What is the relationship between children's height and genetic testing?

Due to the characteristics of short small causes, complex clinical manifestations, overlapping phenotypes in the disease, and high heterogeneous heterogeneity, through conventional methods, only the body can only be detected in the short body of endocrine and chronic systemic diseases. As for the shortness of genetic diseases, if no genetic testing is performed, it is easy to cause missed and misdiagnosis.

Therefore, clinical suggestions, in addition to general examinations such as bone age screening, children with abnormal external characteristics of their height and shortcomings can assist in doing a genetic testing.

Genetic testing is good for:

Determine diagnosis: Auxiliary doctors look for the cause at the level of molecularity, avoid missed diagnosis and misdiagnosis

Judging prognosis: Auxiliary physicians give the treatment plan and evaluate the treatment effect

确 Guide treatment: Clarify the pathogenesis of molecular levels, guide more accurate clinical intervention, drugs, rehabilitation therapy, etc., such as reorganized human growth hormone can treat growth hormone deficiency, glucocorticoids can treat adrenal cortical hyperplasia, vitamin D can treat 佝偻 disease , Insulin can treat diabetes, etc.

： Genetic consultation: help evaluate the risk of illness of family members, and guide the eugenics of patients and other members of the family