The safety of the people on the table of Chinese people!What is it?

China is one of the earliest countries to raise poultry. The history of breeding has a long history.

Today, China is one of the best poultry breeding countries in the world, with an annual breeding volume of more than 18 billion feathers. Among them, the year of poultry in Guangxi ranks fourth in the country. Poultry breeding provides a large number of meat and egg foods for the market. The following related issues such as poultry disease prevention and control are also increasingly valued. This is not only a problem for the development of the industry, but also related to the safety of the Chinese table table. Among the 2021 Guangxi Science and Technology Award winners, there is such a scientific research team focusing on the prevention and control of poultry diseases.

not

In this breeding base in Xingning District, Nanning City, Guangxi, researchers at the Guangxi Veterinary Institute were invited to come to collect and detect samples from breeding chickens. These samples will be sent to the laboratory for testing to confirm whether there are infections such as bird flu virus in the farm.

not

The breeding pays great attention to the prevention and control of the disease, emphasizing the principle of preventing prevention and preventing the treatment. Once a major disease occurs, it is a devastating blow for enterprises.

not

The avian influenza that allows all poultry breeding practitioners to discuss the color of the color. The popularity of bird flu will not only cause huge economic losses of the poultry industry, but also infected people in severe cases, leading to danger of life, and triggering a public health crisis.

Xie Zhixun, a second -level researcher, deputy director of the Guangxi Veterinary Institute, director of the key laboratory of Guangxi Veterinary Technology, has won more than a dozen honorary titles such as the leading talents of the National "Ten Thousand Talents Plan", experts from special allowances of the State Council, and scholars of Guangxi Bayi. After graduating from the Veterinary Vextis of the Guangxi Agricultural College in 1983, Xie Zhixun has been engaged in the research on the prevention and treatment of livestock and poultry infectious diseases and pathogenic molecular biology at the Guangxi Veterinary Institute. During this period, he sent two publicly to the Southeast Poultry Research Institute of the Ministry of Agriculture and Connecticut University for study. Due to the outstanding scientific research results when studying abroad, many foreign research institutions have extended olive branches to him and promised to treat them well, but Xie Zhixun has never been moving. Return to China to play "start from scratch".

not

No matter how hard you work abroad, it is a country where others are building, not your motherland, and you will always be outsiders. We must have a large number of people to participate and build in our country in order to be able to develop. At that time, reform and opening up just started, and many infrastructure and equipment were very simple. When I first returned home, a test tube seemed very precious. Government departments at all levels attach great importance to it, especially the Science and Technology Department, which has allocated a number of instrument and equipment fees. In 1989, 160,000 was a large amount of funds, and I used it to add a lot of necessary instruments to start the laboratory.

not

Despite the difficult start, Xie Zhixun led the young team to overcome difficulties and carried out extensive and in -depth research on the ecology of Guangxi avian influenza pathogen. Over the past 17 years, almost every kind of live birds have been flying from the sky to the ground. There are more than 2,900 bird flu viruses, and more than 430 plants are analyzed in the whole genome.

not

By analysis of samples, the ratio of different hosts infected with bird flu viruses is different. Among them, the probability of water poultry infection is the highest, and its hybrid infection rate is also the highest, which can reach 25.3%. A water poultry can reach up to six mixed infections of different subtype viruses.

Chinese water poultry breeding accounted for about 90%of the total water poultry breeding in the world. In the previous study of bird flu, waterfowls were rarely paid attention to because of rarely their disease and no obvious symptoms.

However, solid research data shows that water poultry is not only prone to infection with bird flu viruses, but also has a high mixed infection rate. It is a "storage library", "mixtor" and "mutant factory" for bird flu viruses.

This discovery quickly opened a new idea of ​​the prevention and control of bird flu virus. Not only that, the team also comprehensively mastered the full genome information and genetic evolution characteristics of different subtypes in Guangxi, clarify the continuity, diversity, and complexity of the mutation of bird flu viruses, and created the Guangxi avian influenza virus resource library and genetic information Library provides a scientific basis for bird flu prevention and control and public health early warning.

not

Some strains of bird flu virus have evolved the potential of infected people and have the ability to combine human receptors. We also revealed that the H9 subtype bird flu virus is a provider of the internal genes of H7N9, H5N6, and H5N8 subtype of avian influenza virus.

The continued in -depth deepening of pathogenic ecology has improved the team's theoretical awareness of avian flu virus. However, in order to truly prevent and control its scientific and control, in terms of key technologies, especially fast differential diagnosis technology, it is necessary to overcome difficulties. Quick diagnosis is the prerequisite and foundation for effective prevention and control of animal diseases. For a long time, the rapid discrimination and typing of different sub -type bird flu viruses have always been a technical bottleneck that plagues clinical. How to solve a single test can only test the problem of one virus, improve the overall test efficiency, the team is brainstorming and the long -term test, after repeated testing, from the high -throughput of rapid identification diagnostic technology. GEXP high -throughput detection technology for different sub -type bird flu viruses.

not

GEXP is a multi -gene expression quantitative analysis system that organizes multiple PCR technology and capillary electrical analysis technology. For the first time, we applied the system to the high -throughput of bird flu and quickly identified the test. For the first time in the world, 8 HA subtypes of HA subtypes that covered all nine NA subtypes and all infected people were established for the first time.

not

The team also innovatively combined immune detection technology with electrochemical sensing technology to open up a new field of nanomaterials (graphene) electrochemical immunosensors diagnosed animal epidemic diseases.

At present, the team has successfully developed a new type of fast diagnosis technology with independent intellectual property rights and full coverage of different sub -type bird flu viruses. There are 7 categories and 45 types of testing and diagnosis methods, of which 42 are internationally first, leading the global avian influenza. Innovation and progress of diagnostic technology.

not

We are amplified by a series of nano -composite materials such as glycene gold nanoparticles and silver nanoparticles as electrochemical signals. The electrochemical detection technology and antigen antibody immune response are organically combined, and the electrochemical immune sensor with good and high sensitivity for the first time is used to detect H5, H7, H9 subtype bird flu virus, and provide the prevention and control of bird flu. Strong technical support.

not

Focusing on all aspects of scientific prevention and control of bird flu, the team has established a comprehensive prevention and control technology system based on biological safety, vaccine immunity, monitoring and diagnosis as a means, and promoting and applied in a large scale in breeding enterprises to help the industry reduce economic losses More than 330 million yuan, which guarantees the healthy and sustainable development of the poultry industry. At the same time, through international training courses, the prevention and control technology of avian influenza is promoted in ASEAN and South Asian countries.

not

Over the years, the Southeast Asian International Animal Disease Prevention and Control Technology Training Course organized by the Veterinary Research Institute of Guangxi Zhuang Autonomous Region has given us the opportunity to contact and learn about the diagnosis and prevention of bird flu diagnosis and prevention. We have promoted and applied the technologies in Laos to improve our ability to prevent and control bird flu. Thank you very much thanked the Guangxi Veterinary Institute for its help and support.

not

Qingshan's seats are towering, and their hearts are brave.

In the past 30 years, Xie Zhixun led the team to pay more attention to the cultivation of local talents, and continuously carried out international exchanges and cooperation in the way of "sending out" and "please come in", and gradually cultivated a poultry research team with an international perspective and a high scientific level.

Through the upper and lower hearts, unremitting efforts, the Biotechnology Research Office of the Guangxi Veterinary Institute won 15 national and provincial and ministerial scientific and technological achievements awards: 1 third prize of national science and technology progress, 2 first prizes for Guangxi Science and Technology Progress 3 and 3 third prizes; 99 national invention patents, 3 US invention patents, and 1 new veterinary drug certificate; published 583 high -level scientific papers, including more than 80 SCIs. In recognition of their outstanding contributions to the prevention and control of animal diseases and economic and social development in my country, the first prize of the Guangxi Science and Technology Progress Award of 2021 will be awarded the Xie Zhixun team again.

not

Xie Zhixun: In the future, we will focus on developing new general -purpose vaccines that have good protection effects on different subtype bird flu viruses, and contribute to our health development and public health security guarantee.

For more exciting, please pay attention

- END -