Be wary of the adverse reaction of "clinithromycin", which can be severely killed!

For medical professionals for reading reference

Evidence -based medicine, reasonable medication

Inocyrin has good antibacterial activity for sensitive positive bacteria and anaerobic bacteria, well -absorbing (90%) orally (except for the cerebrospinal fluid), especially in bone tissue and bile. Convenient, can be used for administration, muscle injection and static drops, and no skin allergies are required before medication, so it is clinically welcomed [1].

What are the clinical applications?

Klinsicin is widely used in clinical application, which can be used for respiratory tract infection, skin and soft tissue infections, sepsis, abdominal infection, female pelvic and genital tract infections, tonsillitis, purulent otitis media, sinusitis, acute bronchitis, chronic bronchitis acute attacks , Consolid infection, urinary system infection, osteomyelitis, oral infection, bone and joint infection, ordinary acne, bacterial vaginal disease.

Although Kylinin is widely used in clinical practice, it is not very safe. Let's take a look at it.

FDA black frame warning: worry about diarrhea, bowel risk [2-3]

According to reports, almost all antibacterial drugs will occur after use (CDAD), including Kylinopolin glucose injection (5%), which may rag from mild diarrhea to fatal colitis Essence The treatment of antibacterial drugs can change the normal intestinal flora, leading to excessive growth of difficultyl bacteria.

Because Klimerin glucocycin injection (5%) may cause severe colonitis and ultimately fatal, this product is only suitable for severe infection that can not be treated with lower toxic antibacterial drugs. Kyromycin is not used in patients with non -bacterial infections, such as most upper respiratory tract infections. Difficulties can produce toxins A and B, which helps the development of CDAD.

The causal strain strain that produces high toxins can lead to an increase in incidence and mortality because these infections may be invalid for antibacterial drugs and may require colon resection.

All patients who have diarrhea after treatment with antibacterial drugs must consider whether they are CDAD. According to reports, CDAD occurred within 2 months after the treatment of antibacterial drugs, so it is necessary to carefully ask the medical history.

If you are suspected or have been diagnosed with CDAD, antibacterial treatment that may not be discontinued may not be targeted at difficultyl bacteria. Proper water and electrolyte management should be performed according to clinical indications, and protein supplementation should be performed, and antibacterial treatment for difficultyl bacteria should be given, and surgery assessment is performed if necessary.

In addition to the black frame warning, what else do you need to pay attention to?

How to adjust the dose of children [4-9]?

This product can be administered for intravenously, and muscle injection can also be administered. Moderate infection: 15-25mg/kg/day, which can be divided into 3 times (once every 8 hours) or 4 times (once every 6 hours); severe infection: 25-40mg/kg/day, which can be divided into 3 Times (once every 8 hours) or 4 times (once every 6 hours).

Babies within 1 month should not be used. Children under the age of 4 use them with caution. When children (newborn to 16 years old) use this product, pay attention to liver and kidney function monitoring.

references:

[1] Tang Ping, Wang Xiangling, Guo Xiaolan, Li Cong Kelincin, 4 cases [J]. Chinese Pharmaceuticals, 2005 (05): 315-316.

[2] Product Information: Clindamycin-CLINDAMYCIN Phosphate Injection, Akorn, Updated January 24,2022.

[3] Product Information: Clindamycin Hydrochloride Capsule, Micro Labs Limited, Updated November 28,2021.

[4] Pharmaceutical Information: Cycin Hydrochloride Capsules, Chongqing Pharmaceutical Friends Pharmaceutical Co., Ltd., Sinopharm Performance H50020507, H50020508.

[5] Pharmaceutical Information: Cycin Hydrochloride Capsules, Chongqing Kerry Pharmaceutical (Group) Co., Ltd., Sinopharm Performance H50020734; 2020/12/01.

[6] Pharmaceutical Information: Klimrin phosphate injection, Shandong Fangming Pharmaceutical Group Co., Ltd., the Chinese medicine quasi -word H20045520; 2020/12/30.

[7] Pharmaceutical Information: Klimrin phosphate injection, Zhejiang Chengyi Pharmaceutical Co., Ltd., Sinopharm Performance H10980178; 2015/12/01.

[8] Drug Information: Cylincin phosphate is used, Changchun Leiyun Pharmaceutical Co., Ltd., Chinese medicine quasi -word H20010160.

[9] Pharmaceutical Information: Cylincin phosphate for injection, Shenzhen Hua Pharmaceutical South Pharmaceutical Co., Ltd., Chinese medicine quasi -word H20143329; 2014/10/10.

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The first release in this article: clinical pharmacy channel in the medical community

Author of this article: Wang Xue, Jie Xiaoshi

Editor in charge: Jingjing

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