AMILIO Case: Science requires rigor, and flora transplantation requires big data!

As the saying goes, if you are in trouble, quantum mechanics, mechanisms are difficult to find, intestinal flora.

Nowadays, intestinal transplantation is a hot topic, and the intestinal flora in our stomach is also a magical micro world.

Decades transplantation is a treatment technology for intestinal diseases. It can rebuild patients' intestinal flora and effectively correct the disorders of intestinal flora. The transplantation process can generally be like an enema, pouring the transplanted flora from the anus of the patient, and the intestinal bacteria can be made into capsules to let the patient take it directly. Decades transplantation is a treatment technology for intestinal diseases. It can rebuild patients' intestinal flora and effectively correct the disorders of intestinal flora.

The data shows that the intestinal flora contains hundreds of trillions of microorganisms, and there are tens of thousands of bacteria, more than 3 million genes, far exceeding the number of genes of their hosts. Through many experiments, the intestinal flora not only affects obesity, chronic diseases, and neuropathy (microorganisms-intestinal-brain-cut-brain axis), and even cancer is closely related.

Human intestine provides a protected and nutritious habitat for microorganisms, while intestinal flora perform metabolism and protection functions for the human body. In addition to the intestinal flora that can help us digest and absorb food, they can also be used as an immunomotive regulation that affects the human body as metabolic organs.

AmiLio, a domestic professional intestinal flora platform, found through big data that only 27 of the 1658 donors (aged 5-51) were healthy bacteria, and the age was between 5-21 years old and the ratio was 0.016%. So why is it so low? Is so many intestines unhealthy?

The proportion of health is so low. Why is the transplantation of fecal bacteria all over the country?

Nowadays, the healthy bacteria liquid that will be obtained by routine will first have a physical examination of the supply, and then the supplier of the physical examination will be collected. Then stir, filtrate, and filter the bacterial solution for the second time. Storage is minus 80 degrees to wait for patient transplantation, but this conventional transplantation often ignores the supply of the donor itself.

The intestinal flora has thousands of different microorganisms, and its metabolites participate in various physiological reactions of the body. The intestinal flora has evolved in the evolution of neuropathic diseases such as Parkinson disease, multiple sclerosis, and Alzheimer's disease Play a huge role in the process. Is that just a simple conventional physical examination and examination, is it the real flora? Intersection

For cases of depression: In another study, when SEGMENTED FILAMENTOUSBACTERIA (SFB) is introduced into a mouse with SFB defects, SFB can produce AI-2 of group induction, and promote the host of the host SAA1 And SAA2, thereby increasing the output of auxiliary T cells 17 (TH17). TH17 cells need to promote depression-like behavior through AI-2, thereby causing sfb-defective mice to have depression symptoms.

In recent years, although the intestinal flora has been a hot topic of research, scientists are still exploring the road of the mechanism, but commercial capital seems to always walk in front of scientific research. The series of health products that help improve the intestinal bacterial flora came into being. A lot of so -called healthy feces can be seen everywhere. A course of treatment is tens of thousands of yuan. Even if there is intestinal diseases temporarily , Now it is not known.

Just eat probiotics?

Wu Long, CEO of Umbrella Biotechnology, feels that at present, some trading platforms, the strange probiotics are everywhere, a small one, the price is hundreds of.

The range of probiotic preparations on the market is extremely effective, including but not limited to: diarrhea, gastrointestinal discomfort, constipation, oral odor, indigestion, gastric soreness, digestion, appetizing, intestinal stress syndrome, lactose intolerance, poor complexion, poor complexion Meridity discomfort, vaginal infection, insomnia, breast inflammation, milk blocking, weight loss, improving immunity, skin allergies, eczema, upper respiratory tract infections ...

Probiotics have become a piomanic medicine, and can be treated everything. Drink a bottle of "hundreds of millions" probiotics rushed to your intestine. Looking at the advertisement and even feeling, probiotics may be able to treat new crowns in the future, HIV, and maybe longevity.

According to the clinical evidence of probiotics listed by the clinical consultant of Uptodate, the magical effects of publicity in advertising have no medical evidence. Of course, in theory, adjusting the intestine has a certain effect, but how many people drink probiotics and medicine to get sick? It can only be said to assist, health products.

Lava -tolerant: Probiotics' benefits to patients with lactose intolerance are yet to be confirmed.

Allergies: Although the study of different probiotic preparations to treat children's characteristic dermatitis has obtained preliminary results of prospects, the exact effect of probiotics on allergic diseases is yet to be confirmed.

Ulcerative colitis: The effect of probiotics in patients with ulcerative colitis has not been confirmed, and all probiotic preparations have not been verified by clinical clinical for ulcerative colitis.

Small intestinal bacteria excessive growth: The effect of probiotics on the excessive growth of small intestinal bacteria has not been confirmed.

Crohn's disease: Standard probiotics' curative effect on Crohn's disease is still to be confirmed.

Hepatogenous brain disease: preliminary research shows that probiotics can improve hepatic brain disease. However, a large META analysis shows that it has no significant benefit to clinical -related endings (such as mortality and survival quality).

Although preliminary studies have proved that probiotics are conducive to improving the intestinal flora, most of the research scale is small, and the probiotic preparations used are very different. Generally speaking, no probiotic strategy at present is considered to be a standard treatment or first -line treatment of any disease. Therefore, in order to solve the disorders of the intestinal flora, it is still necessary to start from the fundamental. Through big data and large -scale research, instead of advertising by some doctors and scholars, there is no need to clinical certification. Is it useful to transplantation?

It must be there. Whether it is domestic or foreign scholars, it has confirmed that the flora transplantation is confirmed through various topic research, and obesity, chronic diseases, neuropathy (microorganism-intestine-brain axis Microbiota-GuT-BRAIN AXIS), or even even Cancer is also closely related.

Studies are not equal to clinical guidance

Each of our intestinal flora is unique, and the types and quantities of the flora are affected by many factors such as heredity, diet selection, physical fitness, lifestyle, and antibiotics.

In turn, the intestinal flora has also played an important role in human metabolism. The intestinal flora and the human body continue to interact in various ways, forming a complex symbiotic network.

The intestinal flora transplantation needs to be more careful. By researching the big data of the intestinal flora of patients, a large -scale research, rather than about 10 supply flora can confirm the experimental results, and even need to be different in different regions. , Age, gender, occupation, cultural level, and family genetic diseases.

The intestinal flora transplant is indeed a few years or even more than ten years as some doctors and scholars say, but as long as the big data is done well, widely and targeted research experiments, and the intestinal flora in the future will even be even It can solve obesity, chronic diseases, neuropathy, and even cancer and other diseases.

This article is only the author's personal point of view. If there is any objection, you can discuss each other.

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