Note that these six drugs may make people "weighty"!

For medical professionals for reading reference

Not only is we getting too much because I eat too much

In addition to those friends who like to eat Heshe but do not like sports, there are some people who pay attention to their diet and exercise, but they are still gaining weight! Why is this?

This so -called "drinking cold water grows meat" may be caused by drugs!

01 insulin

Insulin can cause obesity, and the mechanism of weight gain may be the following aspects:

Insulin therapy can better control blood glucose, thereby reducing the excretion of glucose in the urine, so that the calories lost from the urine are reduced.

Insulin itself has the effect of directly promoting fat tissue lipid synthesis. Insulin secreted insulin first through the liver, so most of the insulin had been cleared by the liver before reaching the tissue.

The exogenous insulin first reaches peripheral tissue, such as fat, muscles, etc., and then enters the liver.

Therefore, during insulin treatment, fat synthesis is increased due to excessive exogenous insulin concentration.

Insulin therapy is common adverse reactions is hypoglycemia, and hypoglycemia can cause patients to eat defensive feeding, thereby intake of more calories and increase weight.

However, there is an exception in insulin preparations. Studies have shown that the risk of hypoglycemia (including low blood sugar at night) is significantly reduced while effectively controlling blood sugar, and it shows the advantages of unique weight gain [8].

The weight advantage of ground special insulin is reflected in different constitution index (BMI), glycated hemoglobin (HBA1C), or aged people, but it is more prominent in some groups, such as high -base line BMI, HBA1C patients, etc. [9].

02 Oral hypoglycemic medicine

Part of the hypoglycemic drugs (TZDS) hypoglycemic drugs will affect the endocrine system and improve the level of metabolism in the body. Therefore, there are adverse reactions to gain weight [6].

However, some studies have found that the results of TZDS on weight effects are inconsistent. Adopt research shows that TZDS will increase weight [7]. Similar research results are also verified in the Dream test, while the results of China's confidence research indicate that pyrite has no effect on weight and can reduce the waist circumference.

In addition, the commonly used sulfur and Greya drugs commonly used in the clinic are insulin promotion agents and also have the effect of increasing weight.

03 glucocorticoid

It is mainly cortisol. Long -term large doses of large doses can cause cortisol hydodiaflate.

04 progesterone drug

1

Gyeurine

MEGESTROLOLOLOLOLOLOLOLOLOLOLOLOLAAOATINISTIN is a progesterone drug that is mainly used to treat metastatic breast cancer and endometrial cancer that depends on hormone growth.

Increased weight and appetite are the most prominent and typical adverse reactions. The incidence of weight gain is 81 % -88 %, and the incidence of appetite is 53 % [4].

Clinical studies have shown that the weight gain is mainly the increase in adipose tissue rather than muscle tissue, which is not necessarily related to the accumulation of liquid (that is, the long is pure fat).

However, it is precisely because of this special effect that clinically is often used to treat anorexia and evil quality of patients with advanced cancer patients, which can significantly improve the quality of life of patients with advanced cancer [4].

2

Zuojinourone

The main form of the drug in the clinical application is the left-noconurone intrauterine slow release system (LNG-IUS). Some studies have pointed out that the individual difference in weight changes in the preparation is very different. LNG-IUS does not necessarily lead Increased weight [5].

05 antidepressant

The "Monitoring of Anti -depression -related Evilistions in Adult Depression Therapy" issued by the World Biological Psychiatric Society (WFSBP) mentioned that when the antidepressant treatment drug (SSRIS) treatment of severe depression (MDD) was mentioned. As a result, the patient's weight gain or obesity.

And obesity can also lead to a reduction in the reaction of patients' anti -depression drugs, and women who take long time are more likely to gain weight or obesity.

Among all antidepressants, the risk of weight gain or obesity of the three -ring antidepressant (TCAS) drugs is the highest [3]. Monamoxylase inhibitors (MAOIS, such as benzene, benzene, alien papo, chloribalamamine, and tolosol) can also cause weight gain. Weak [1].

06 Other drugs

Other drugs include atypical anti -psychiatric drug chlorine, octophyla, sulfuri, and Lipipidone;

Sodium propyate and Ramolezine in antiepile epilepsy;

Animidazole, Mimizole, Tetfidin and ketonfen in H1 receptor antagonists.

Fatty is already so difficult

Don't disassemble some things

When prescribing the above -mentioned related drugs, doctors should do a good job of medication and ask patients if there is a plan to lose weight in the near future. If patients need to control weight, they need to choose the appropriate treatment plan according to the patient's situation to avoid drugs that cause obesity.

If the patient has begun to take these drugs and produce a bad response to the weight gain, diet and living habits should be adjusted in time, focusing on nutrition and behavioral therapy. Limit sugar and fat diets, strengthen exercise, and monitor weight changes.

Is there any harvest after reading? Repost and share at any time to let more people see!

Reference materials:

[1] Zhou Jianying, Gao Xiaoya, Ma Xianghua. The research progress of obesity related to drug-related obesity [J]. International endocrine metabolism magazine, 2006,26 (01): 32-34. Ferin treatment with a functional gastrointestinal disease that is accompanied by depression or anxiety [J]. Chinese new medicine and clinical magazine, 2002 (11): 693-695.

[3]Dodd S , Mitchell P B , Bauer M , et al. Monitoring for antidepressant-associated adverse events in the treatment of patients with major depressive disorder: An international consensus statement[J]. World J Biol Psychiatry, 2017:1-19 Then, then, then

[4] Lu Yi, Wu Hongbin. Adverse reactions of Grand Graceurone [J]. Pharmaceutical adverse reaction magazine, 2003 (01): 26-28.

[5] Lang Jinghe, Cold Jinhua, Dunshan, waiting for the clinical application of Chinese experts in the clinical application of Zuo Nuo Permithu Palace [J]. Chinese Women's Magazine, 2019, 54 (12): 815-825 Then, then, then

[6] Chinese Medical Association, Clinical Pharmaceutical Branch of the Chinese Medical Association, Magazine of the Chinese Medical Association, waiting for the reasonable medication guide at the grassroots level of type 2 diabetes [J]. Chinese general physician magazine, 2021, 20 (6): 615-630.

[7] Zhao Yizheng, Wang Kun, Liu Chao. Cycles of the clinical practical value and safety of dioneyl drugs [J]. International endocrine metabolism magazine, 2019,39 (4): 236-240.

[8] Pan Changyu. Daily injection of long-lasting special insulin: significant reduction of weight gain and hypoglycemia [J]. International endocrine metabolism magazine, 2008,28 (03): 155-157.

[9] Kuang Hongyu. Ditecin and diabetes individualized treatment [J]. China Diabetes Magazine, 2014,6 (1): 56-58.

The first release in this article: clinical pharmacy channel in the medical community

Author of this article: radish white Cai

Editor in charge: Wen Jiaxin

- END -