"Everything about Dr. Tang" is beautiful, and contraceptives will affect other efficacy?

Recently, the TV series "About Dr. Tang" on the theme of medical care was broadcast. This medical industry drama has deepened the medical staff's benevolence through vivid and vivid cases.

Most of the cases in the play are adapted from real cases. For example, cases shown in episodes 11 have aroused widespread attention.

In the play, the patient was replaced by the heart valve, and the postoperative recovery was recovered well, but the heartbeat breathing arrest was stopped the night before discharge, and the rescue died invalid. The cause of the death of the autopsy is: "complications after replacement".

According to the diagnosis and treatment specifications, oral Huafa as the anticoagulant therapy after the valve replacement of the cardiac valve can prevent thrombosis. What is puzzled by everyone is that the patient has always followed the doctor's instructions to take Huafarin after surgery, but why does this result appear? Intersection

After further investigation, the patient had undergone artificial abortion surgery before hospitalization and took contraceptives after surgery. Although the contraceptive pill was discontinued during this admission treatment, a large number of contraceptives were taken on the day of the sudden cerebral infarction. Forensic doctors found that there are indeed a large amount of estrogen in the body.

As a result, the ultimate "culprit" is contraceptives! Intersection Intersection It affects the anticoagulation effect of Huafalin!

"What kind of murmurs?! Contraceptives would affect the effect of other medicines!" This conclusion was shocking at the same time, and puzzled.

Below is invited Ma Qing Pharmacist, the Ministry of Pharmacy of the Third People's Hospital of Chengdu.

1. Why does contraceptive affect the effect of Huafalin?

Huafarin is a commonly used anticoagulant drug that prevents the formation and development of thrombosis by inhibiting the synthesis of intrapatic coagulation factors. Most contraceptives contain estrogen and progesterone. These two hormones will compete for related liver enzyme proteins to promote the synthesis of coagulation factor. At the same time, it will induce liver enzyme activity to increase the degradation of Huafarin.

In other words, under interaction, the treatment effect of Huafarin will be reduced, which cannot exert the ideal anticoagulant effect.

Can the two medicines be completely unavailable at all?

The answer is to be used. However, it should be reminded that when taking Huafarin, whether it is a patient group who has just begun or has just discontinued contraceptives, it is necessary to measure the coagulation function of 1-2 times a week to adjust the amount of Huafarin as appropriate. To play its anticoagulation effect.

2. What drugs will contraceptives affect each other?

It should be noted that contraceptive pills may affect other drugs and may also be affected by other drugs.

3. How to avoid the risk of merging medicine?

Medication of consolidated medication is a common treatment for clinical, but the following matters need to be paid attention to during the medication:

During the consultation, you must tell the doctor or pharmacist's own medication history, including the drugs that are taking, and other medicines that have been taken in the past two weeks.

During the medication, you must follow the doctor's advice. Do not change your own or take other drugs to avoid interaction between drugs and affect the treatment effect.

(Contribution of Chengdu Third People's Hospital)

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