Gao Fu and Zhang Wenhong talked about monkey acne epidemic: my country has input risks

07.08.2022

Number of this text: 1875, the reading time is about 3 minutes older

Introduction: As of now, there have been no cases of monkey acne infection in mainland China, but in the face of this kind of rapidly spreading infectious virus in the world, it is imminent to launch targeted research and preparation for prevention and control.

Author | First Financial Money Children's Heart

The new crown epidemic has not yet ended, and the epidemic of monkey acne outbreaks in Europe and the United States. The task of human response to infectious diseases is still arduous.

On July 23, the World Health Organization (WHO) announced that monkey acne epidemic occurred in many countries and regions constituted "Public Health Emergency of International Concern (PHEIC). On August 4th, the United States announced its entry into a state of public health to strengthen the response to the epidemic of monkey acne.

As of now, there have been no cases of monkey acne virus infection in mainland China, but in the face of this rapidly spreading infectious virus in the world, it is imminent to launch targeted research and preparation for prevention and control.

The third and fourth generation communication began to accelerate

On August 7, at the "Monkey Acne Virus Research and Prevention and Control Forum" initiated by the Shanghai BAAS Institute of Chinese Academy of Sciences, Professor Zhang Wenhong, Academician Gao Fu, Institute of Microbiology, Institute of Microbiology of the Chinese Academy of Sciences, The input risk of monkey acne virus in my country was warned.

Gao Fu said that the newly developed sudden infectious diseases, including the new crowns, continued to have a huge impact on human health. The two most important things that humans can do are monitoring, the other is basic research Essence

Gao Fu believes that it is necessary to prepare for the input cases of monkey acne input that may occur in my country in the future, maintain high vigilance, strict monitoring, and propose early warning signals in a timely manner. These tasks will help researchers to develop countermeasures to respond to monkey acne virus.

"Although my country is not yet great due to the prevention and control of the new crown epidemic, the input pressure of monkey acne is not very large, but once our border is opened, this virus is likely to enter China, so we should be important for this important one. The incident pays attention. "Gao Fu said.

At present, the WHO believes that the risk of monkey acne in my country is low -risk, and Europe is a high -risk zone. Gao Fu also said that although humans and monkey acne "have been confronted for a long time, they have not understood the virus enough and have less research and deployment. For example, in 2019, people have finally figured out the RNA polymerase of the monkey acne virus.

Gao Fu called for the development of vaccines, especially the MRNA vaccine technology. "We are not very clear about the impact of weak poison seedlings on the human immune system. What is better is to develop a mRNA or protein vaccine." Gao Fu said.

So far, the only virus in human history is only smallpox, and the spinal ash quality distance is destroyed and there is "last mile". Zhang Wenhong said that the factors that promote the eradication of the virus include: human beings are the only virus host, effective and periodic vaccine.

Zhang Wenhong said: "Every time the virus completes the jump of cross -object transmission, the type of disease will change a lot. Therefore, the virus needs to be closely monitored and studied, so that the transmission and pathogenicity of the virus need to be more. Ok, I understand."

He believes that for the transmission of monkey acne viruses in the past, the spread of interpersonal interpersonal is relatively weak, and rarely the third -generation or even the fourth generation spread. However, from the perspective of the epidemic, the third and fourth generation of the fourth generation Propaganda began to accelerate. "We need to figure out the variation of the virus and how human activities affect the acceleration of spreading." Zhang Wenhong said.

Detection and treatment means to keep up

Zhang Wenhong also analyzed the human infection of monkey acne virus from the perspective of clinical symptoms and treatment. He pointed out that from the clinical characteristics, almost all cases have rash or skin damage, and 60 % of cases have fever and lymphadenopathy. However, he emphasized that in the non -influx area of ​​the epidemic outbreak of this time, the clinical symptoms of patients were not typical, and the condition was relatively mild.

From the perspective of treatment, there are no special effects for monkey acne, but several drugs such as smallpox and other diseases may be useful for monkey acne, including Vistide, and specificity Immunoglobulin and so on.

In the United States, the US FDA approved a drug called Tecovirmat in 2018 for the treatment of adults and children's ceilings, and the drug has been added to a strategic reserve. In 2021, the US FDA approved Brincidofovir oral medicine, and other potential drugs also In research and development.

Zhang Wenhong said that although there are no confirmed cases of acne in mainland China, the relevant departments have realized that the outbreak of the monkey acne is different from the previous sporadic outbreak, and there is a risk of input cases. Increasing, we need to be vigilant and beware of the popularity of the disease in my country.

Nicolas Berthet, a researcher and a monkey acne expert in the Shanghai Bassurg Institute of the Chinese Academy of Sciences, believes that for a long time, monkey acne has been ignored infectious diseases, which is related to most cases of previous cases. Berthet told the First Financial reporter that the popular monkey acne virus strains that were popular in the world belonged to a branch of West African branch.

He believes that in the past 5 years, whether the acne poison strains that spread among Nigeria in 2017 have been spreading at low levels around the world at low levels; in addition, whether the virus has obtained the ability to more adapt to interpersonal transmission through mutations,, Thus accelerating the spread between people is also worth studying.Berthet also proposes that the ability to detect monkey acne virus should be strengthened."Although our current testing reagents are not targeted at the latest popular monkey acne strains, they still have the ability to detect viruses." He said, "Strengthening the detection capacity in countries and regions where monkeys are popular.Global spread; gene sequencing is also very important, you can find the target of virus adaptation through sequencing. "

Liang Xiaozhen, a researcher at the Shanghai Bastend Institute of Chinese Academy of Sciences, also urged that more scientific research resources and research strength should be invested in the molecular mechanism of monkey acne virus infection and host immune response to promote deeper research.

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