The fourth case of AIDS "healing" may have appeared

According to foreign media sources, researchers reported on July 27 that a 66 -year -old leukemia patient had long -term relief after receiving stem cell transplantation or "cure". This is AIDS patients in the world who have been "cured" and the oldest patients are currently the largest patients.

HIV virus color electronic microscope image. Source: US Broadcasting Company website

The patient was treated in the city medical center of Hope in Du Alt, California, USA. Because of its unwilling name, it is called a "city of hope". At present, he has not received anti -inverted virus treatment (ART) for 17 months, but no signs of AIDS virus (HIV) have not yet appeared in the body.

In addition to the oldest age, the patient was the longest infection with HIV. He was diagnosed with AIDS in 1988. For 30 years, he has been accepting Art to control his condition, but he has not effectively treated AIDS.

In 2018, the patient suffered from acute marrow leukemia (AML), a blood and bone marrow cancer. He received chemotherapy to relieve leukemia. Due to the older age, he received a lower intensity chemotherapy and prepared for stem cell transplantation.

Subsequently, the doctor used the cells with a donor carrying rare gene mutations for hematopoietic stem cell transplantation. This mutation called purehe CCR5 Delta 32 is usually used to invade the virus's entrance to the entrance of the human white blood cells, so that the carrier has anti -drug resistance to HIV. Bleeding stem cell transplantation is a improved therapy. Elderly people with blood cancer can better tolerate and reduce the possibility of transplantation -related complications. This method was originally cured in 2007 "Berlin patient" Timoshi Lei Brown.

The "City of Hope" stopped accepting ART in March 2021. The team said his AIDS and leukemia had been relieved for more than a year.

Before the 24th International AIDS Conference (AIDS 2022) held on the 29th, the doctor who submitted the data stated that this case provided the possibility of treatment for elderly patients with AIDS and blood cancer, especially in the supply body is not a family member. in the case of.

Sharon Levin, chairman of the International AIDS Association, said that this case provides "continuous hope and encouragement" for HIV carriers and a wider scientific community, although due to surgical risks, it is unlikely to become most HIV carriers. The choice of the person.

Scientists believe that the reason why this process is effective is that the donor's stem cells have a special, rare gene mutation, which means that they lack the receptors used to infect cells infected by HIV.

On the 27th, researchers in Spain also announced a detailed information of a 59 -year -old woman. She is one of the few groups called "after treatment". Levin said that although she stopped accepting ART, her body still kept the virus load that could not be detected within 15 years, which could provide clues for potential treatment. Source: Science and Technology Daily

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