Why do you pay attention to renal function and what else do you pay attention to when taking Rouhouvastine?

A friend left a message asking Huazi, what precautions did Rizhuvastatt take? Hua Zi said that Ruhouvastin is one of the powerful and strongbatin, and the other powerful bitin is Attin. When taking Rouhouvas, you need to pay attention not to exceed the safety dose and the requirements for renal function.

When taking Rouhouvas, it has requirements for renal function. It does not damage the kidneys, but some Ruhunvastin needs to be excreted through the kidneys. If the renal function is not good, it is easy to cause Ruhouzabatin to accumulate and increase toxic reactions. In fact, Ruhouvas has a protective effect on the kidneys.

1. The largest dose at home and abroad

Friends who have experienced in foreign countries told Huazi that the largest dose of Ruchus Invisin in foreign countries can take 40mg daily, but the biggest dose of domestic Ruhouzanda is 20 mg per day. Is the dose "dual standard", is it the cause of the drug?

Huazi said that this situation has nothing to do with drugs, but the constitution of the Chinese is different from foreigners, and has low tolerance to his drugs. The Ruhouvasch is particularly obvious. Under the same dose, the Chinese people's drug concentration curve area is twice that of European and Americans.

Therefore, in order to reduce adverse reactions, the largest dose of Ruhouvastin in foreign countries is 40 mg per day, and the largest dose in China has been reduced by half, which is 20mg per day.

Second, Ru Shuzanda, who has the effect of kidney protection

Because the drug instructions are banned from those with severe renal function, many people think that Ru Shuzardine has an impact on the kidneys. However, this is a misunderstanding. A small part of Ruhouvastin needs to be excreted through the kidneys. People with severe incomplete renal function (creatinine clearance <30ml/min). Drug excretion will cause obstacles, which will cause drug accumulation and toxic response.

However, for people with mild and moderate renal dysfunction, taking Ruhouvastatin does not affect the excretion of drugs, and by reducing blood lipids and renal atherosclerosis, improving kidney blood supply, in fact, it has a protective effect on the kidneys.

In a large dose (40 mg daily) test, most cases observe the short and intermittent proteinuria, but it is not considered a precursor to kidney disease.

Third, Ruhunpastatin and Atropine

In the clinical trials of Rouhouvas, the level of low-density lipoprotein cholesterol (LDL-C) can be reduced by about 63%in foreign clinical trials, which is the most lipid-lowering intensity. Attica can reduce the level of LDL-C by about 55%.

However, the incidence of adverse reactions is slightly higher compared to the Attin Bather, so when initially treating the initialbine treatment, the Atropastatin is usually selected. Guan Ting.

Avastein needs to be metabolized through liver pharmacies, and it will interact with many drugs. The Ruhunvastatin has only a small part of the hepatic enzyme metabolism and has less interaction with other drugs. Patients with a variety of diseases coexist when they need multi -medicine combination, and they are more suitable for the use of Ruhouzanda.

Fourth, pay attention to adverse reactions when using

In the process of medication, pay attention to the impact on liver function. Although Rusouvas has rarely metabolized the liver, its "work place" is in liver cells and may affect liver function. Therefore, pay attention to the level of transaminase (AST, ALT) during the medication. When the normal upper limit is 3 times, it is recommended to stop the medicine.

Heating drugs have adverse reactions of muscle injury. During the medication, muscle soreness and fatigue may occur, and it may also cause rare, but there is a fatal and dangerous horizontal muscle solubility. Therefore, pay attention to the compound muscle kinase (CK) during the medication. When the normal upper limit is 5 times, the medicine should be discontinued.

Ruhouvas can cause blood glucose abnormalities and increase risk of new diabetes. However, rising blood sugar is not a indicator of drug discontinuation. It is recommended to use hypoglycemic drugs to control blood sugar to maintain his treatment as much as possible.

To sum up, Ruhouvasch will not hurt the kidneys, but those with severe renal function will affect the excretion of the drug and may accumulate poisoning. Ruhouvas has less interaction with other drugs, which is more suitable for multi -drug combination. Pay attention to adverse reactions during the medication. In the first month, 3rd month, and 6th month of the medication, it is recommended to review blood lipids, liver, kidney skills, and creatine kinases to evaluate drug effects and prevent adverse reactions.

Drugs need to be taken under the guidance of a doctor, and have doubts about medication. Please consult a doctor or pharmacist. I am a pharmacist, and welcome to follow me and share more health knowledge.

- END -