Can Azf, which has begun mass production, must be the "Terminator" of the New Crown Epidemic?These questions you care about have answers!

Editor's note: In the recent time, Azf's fixed film, as the first domestic anti -new crown oral medication, has attracted much attention. On August 2, Azf's fixed film was officially put into production in Pingdingshan, Henan, marking the development of a new chapter in the development of the biomedical industry in Henan Province. The victory over the new crown pneumonia contributed the "Chinese power".

From now on, Elephant News will launch a series of "Henan" Medicine "self -improvement, focusing on hot issues that the public cares about and pay attention to the development of the development of the biomedical industry in Henan. Today's first launch "Whether Azf, who has begun mass production will be the authoritative answer you care about if you can be the Terminator of the New Crown Epidemic!"

Elephant reporter Wang Lin/Wen Tu Zhang Ziqi Lu Jiamin/Video

On August 2nd, Azf was officially put into production in Pingdingshan, Henan Province. This is also my country's first self -containing small molecule medicine for self -intellectual property rights. Once the news was announced, it attracted a lot of attention. A few days ago, the State Drug Administration had the conditions to approve the application of Henan Real Biotechnology Co., Ltd. Azf's fixed film to increase the application for registration of new crown pneumonia.

What is the effect of this "domestic" anti -new crown "special effect medicine"? Is it safe to take? Is it possible to become the terminator of the new crown epidemic? In response, an elephant reporter interviewed the Azf drug inventor and Henan Normal University Professor Chang Junbiao and other experts conducted authoritative answers to the relevant hot issues that the public paid attention to.

[Focus 1] How is the effect of Azfding, is it effective for Delta virus, etc.?

As the first oral small molecular medicine for domestic anti -new crowns, what exactly is Azf and how the efficacy is the focus of everyone's attention.

"Azf must be a nucleoside drug that suppress the virus RNA -dependent RNA polymerase (RDRP). It can specific effects on the new coronary virus RDRP, thereby inhibiting virus replication, and its drug is targeted." According to Az Chang Junbiao, an inventor of Fu Ding Pharmaceutical and Professor of Henan Normal University.

According to public information, the results of the registered clinical trials of Azf's phase III show that Azf's fixed tablet can significantly shorten the moderate new type of coronary virus infection with the symptoms of pneumonia. Essence

Clinical data shows that the proportion of subjects in the 7th day of the 7th day after the administration was 40.43%, the placebo group was 10.87%(P value <0.001), and the medium time of the improving clinical symptoms of the subjects was There are very significant statistical differences in the setting of Zif's setting and placebo group (P value <0.001). The results show that Azf will definitely inhibit the activity of the new coronal virus, and the virus clearance time is about 5 days.

In an interview with Elephant News, Chang Junbiao usually takes medication, especially for virus load (by measurement and displaying the number of viruses per milliliter of blood). After 5 days or 5 days, it can generally decrease 0.5 LOG, which has already indicated that the effect of the drug is very good. After testing, Azf's testimony has proven that this medicine can decrease more than 2 logs, which also means that its ability to inhibit virus copy is very strong.

Academician Jiang Jiandong of the Academy of Pharmaceuticals of the Chinese Academy of Medical Sciences also said that Azf has a significant anti -new coronal virus effect and is effective for patients with clinical severe illnesses.

[Focus 2] How can Azf take medicine, does it have side effects?

In the case of effective drugs, can the medication be guaranteed to ensure safety? Is there any side effects?

"The safety of this medicine is guaranteed. Previously, as a drug that was anti -AIDS, it was listed last year." Chang Junbiao was confident in the safety of the drug.

For the security of Azfdin, in addition to the full market verification, Chang Junbiao explained that after the drug reaches the body, if it is damaged to the normal cells of the human body, it is the side effects of the drug. However, after a large number of experiments, Azf's accumulation in the body was 5 days, and there was no damage to normal cells. It only suppressed the virus copy of specific cells.

"Moreover, when treating the new crown, the dose of this medicine is very small. Each person only needs to take 5 mg per day, and the side effects are small." Chang Junbiao added. In this regard, Cen Xiaobo, director of the National Chengdu New Medicine Safety Evaluation Center, also said in an interview with the media, "It is unscientific The "genetic toxicity" and "reproductive toxicity" mentioned in the fixed review report, ordinary patients do not need to worry too much.

[Focus 3] How can Azf inhibit the new crown virus?

Many people are curious, how can Azf inhibit the new crown virus?

In this regard, Chang Junbiao also explained in detail in an interview with Elephant Journalists. He said that the new coronal virus is a RNA virus that will destroy the human body's immune system after arriving in the body. At the beginning, the amount of viruses invaded the human body was very small, but they would copy a lot in the cells. In the process of copying, the human body's own immune system will be activated. If the virus is replicated, the entire organ is activated, and the organs will fail.

However, because the RNA virus is a single -chain virus, they are paired through nucleotide base, and they pull their hands one by one. The drug will inhibit the copy of the virus after reaching the body. That is to say, it is suddenly interrupted in a place, the virus copy is suppressed, and the disease will slowly be better.

In addition, Chang Junbiao also mentioned that because Azf's half -life in immune cells is 120 hours, orally can last for 5 days, and the drug has always played a role in the body. Then, as long as the virus comes in, it can work and inhibit the virus.

[Focusing 4] What is the special thing about Azf compared with the already anti -new crown drugs on the market?

"Small dosage, both specimens and low prices are its main features." Compared with the current anti -new crown drugs on the market, Chang Junbiao simply attributed the advantages of Azf to several words.

He explained that the amount of Azfdin is very small, and each person only needs 5 mg per day. Compared with the current imported drugs, taking Pfizer's medicine that everyone is well known as an example, the daily consumption of each person is 800 mg, while Azfdin's use is only 1/120, and the side effects are very small.

"On the other hand, due to the characteristics of the structure and the mechanism of action, Azf's decision to achieve both the symptoms and the treatment." Chang Junbiao told Elephant Journalists that the half -life of Azf's drug concentration in the slurry was 120 hours. Once orally, it has a long time in the human body paste, which also means that it can not only be replicated in the peripheral blood, but also the effect of the virus in the paste to achieve the effect of both the symptoms.

In addition, as a drug in my country with independent intellectual property rights, Azf will undoubtedly have a great advantage in price. "It will be much cheaper than foreign medicines. The specific price needs to wait for the State Medical Insurance Bureau to formulate it." Chang Junbiao said.

[Focus 5] When will Azf be listed, can the treatment of new crowns be like treating colds?

As a highly watched anti -new crown oral small molecular drug, when will the drug be listed on the premise of ensuring the efficacy and safety of the drug? How much is the price?

Chang Junbiao told reporters that in fact, when the National Drug Administration was approved, in principle, it was already available. "The approval of the State Drug Administration is based on the listing approval. This medicine must be mass -produced."

On August 2, the reporter obtained the latest news, and Azf's setting was held in Pingdingshan, Henan. In addition, as early as May of this year, the real biological Pingdingshan production base has passed the standardized inspection of the quality management of drug production organized by the Provincial Pharmaceutical Supervision Bureau, marking that the company's own production bases can comply with the production and operation of drugs. It is reported that the total construction area of ​​the base is 32,000 square meters, and the annual output of the future preparation can reach 3 billion pieces.

Is this medicine likely to be the terminator of the new crown epidemic? In this regard, Chang Junbiao replied that "I hope it is the terminator of the new crown epidemic. By then, just like treating a cold, you can treat it as long as you take medicine."

When it comes to price issues that the public cares about, Chang Junbiao said that the relevant national departments are currently communicating and coordinating. However, he predicts that the price (a box) should not exceed 1,000 yuan.

[Focus 6] Is this medicine likely to be suitable for children in the future?

It is understood that Azf's new indication approved for this time is "adult patients used to treat ordinary new coronary virus pneumonia (COVID-19)", so will this medicine may be suitable for children in the future?

Chang Junbiao told reporters that drug research and development is a very serious matter. The clinical trials made this time are not as children in choice. In other words, if this medicine will be used for children in the future, it must also go through clinical trials specifically for children. This is very strict.

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