[Transfer] Nearly 1/3 people suffer from non -alcoholic fatty hepatitis, which has nothing to do with drinking

[Transfer] Nearly 1/3 of our country suffers from non -alcoholic fatty hepatitis, which has nothing to do with drinking!

Source: Gitzo Pharmaceutical

Recently, Aunt Wang accompanied the hospital to the hospital for a full body test, but she did not expect that she had suffered from fatty liver. Aunt Wang questioned the results of the inspection.

Aunt Wang: "I haven't touched wine from birth to now.

Doctor: "Drinking is indeed the most common factor with fatty liver, but this does not mean that fatty liver will not occur without drinking. Auntie, you have non -alcoholic fatty hepatitis, and have nothing to do with drinking! "

Aunt Wang: "It has nothing to do with drinking? So what did I suddenly get fatty liver?"

Doctor: "This kind of fatty liver you get has a big risk factor, that is, obesity, do you think about it carefully, do you usually don't pay attention to exercise? Is the calories of meals not control at all? So, although fat is fat, although fat is fat Thin is not the only criterion for judging beauty and ugliness, but it is the source of your fatty liver! "

For doctors in the department of liver disease, the above scene can be described as happening every day. I do n’t know how many times drinking is the only factor that causes fatty liver. Obesity can also cause non -alcoholic fatty liver, but asking this question about this question Patients are endless. It can be seen that the public's understanding of fatty liver is very lacking, and the popular science work of fatty liver is far away!

What is the non -alcoholic fatty liver in my country?

As the Chinese medicine is said, the year of the year lies in spring, and the liver is not losing the spring. A study in 2015 showed that the prevalence of global non -alcoholic fatty hepatitis has reached 25%, and the prevalence of the prevalence in Asia has also reached 27%. According to relevant domestic research, China is currently not in my country. The prevalence of alcoholic fatty hepatitis also reached 29.2%[2]. Nearly 1/3 of the people were plagued by non -alcoholic fatty hepatitis. It can be said that non -alcoholic fatty hepatitis has become The main disease of global chronic liver disease.

The disease is as famous as its name. Non -alcoholic fatty hepatitis is a disease that can cause hepatocyte damage, liver fat degeneration, inflammatory cells, and even fibrosis caused by non -alcoholic factors. It is easy to develop into liver cirrhosis and liver cancer, and it also greatly increases the probability of cardiovascular disease [3].

How does non -alcoholic fatty liver happen?

There are many causes of non -alcoholic fatty hepatitis. Hereditary, sugar -lipid metabolic disorder, stress and mitochondrial metabolism disorders, inherent immune response changes, and changes in intestinal flora are its main pathogenic factor. The thyroid dysfunction, obesity, and diabetes will further promote or increase the onset or condition of non -alcoholic fatty hepatitis.

Non -alcoholic fatty hepatitis is hidden, and the course of the disease is also extremely slow. Many patients do not have specific clinical symptoms in the early stages of illness, or only fatigue, decreased appetite or mild abdominal pain and liver region pain, which is easy Everyone ignored it that it could not give professional clinical intervention as soon as possible to the condition, which led to the preliminary diagnosis that there was a performance of liver fibrosis of more than 2 or more. As the disease progressed, more than 20%of patients would develop into an irreversible liver. Research -Studies have shown that the incidence of liver sclerosis within 10 years is as high as 15%to 25%[3].

What are the methods of treating non -alcoholic fatty hepatitis?

Although the incidence of non -alcoholic fatty hepatitis has continued to grow in a worrying trend, based on the complexity of this disease, it has not been able to be widely used clinically. Intervention in lifestyle and surgery and drug treatment to reduce or reverse patients' fat degeneration and inflammation and improve fibrosis.

1. Lifetime intervention

1) Reducing weight: Obesity is an important risk factor that causes non -alcoholic fatty hepatitis. Studies have shown that if patients can successfully reduce weight by more than 5%within one year, the degree of degeneration of liver fat can be reduced, and weight loss is 7 ~ 10%can effectively reduce the level of liver enzymes and improve the inflammation of the leaflets. If it can reduce weight by more than 10%or even play a role in reverse the liver fibrosis [4]

2) Diet adjustment: In 2020, the Latin America Liver Research Association Nafld Diagnosis and Treatment Guide pointed out that the daily medium -sized coffee intake and the Mediterranean diet are conducive to improving non -alcoholic fatty hepatitis. The Mediterranean diet, that is, eat more fresh fruits and vegetables, whole grains and soy foods. Use chicken, duck, fish and fish to replace red meat, use olive oil or rapeseed oil as edible oil, and use spices to replace salt to season [4].

3) Strengthen exercise: Strengthen exercise, reduce the degeneration of liver fat through regular aerobic exercise and resistance exercise, thereby achieving the purpose of alleviating the disease [4].

2. Surgical treatment

Surgical treatment is mainly due to weight loss surgery and liver transplantation. Among them, for patients who have mild and obese but fail to achieve the effects of controlling blood sugar and severe obesity, and patients with refractory obesity and recurrence of liver transplantation, weight loss surgery can maintain the patient's physical quality in a relatively ideal. The state of the state, effectively control the disorders of metabolism, and effectively reduce the risk of cardiovascular adverse incidents [4].

3. Drug treatment

Drug research and development of non -alcoholic fatty hepatitis is passionate, and more and more disease pathways are participating in clinical drug research and development of this disease as potential targets, in order to use antioxidant, improve liver inflammation and sugar fat metabolism. Anti -fibrosis to improve this disease [5]. At present, a number of tertiary hospitals in my country are conducting a clinical research on treating adult non -alcoholic fatty hepatitis (NASH). If you meet all the conditions and sign the consent of informed consent, you can participate in this study.

It is believed that with the continuous research and development of new drugs, it will eventually bring a breakthrough in the treatment of non -alcoholic fatty hepatitis.

references:

[1] Golden Tiger, Ding Jin, Liu Mingjiang, Jiang Keqing, Zhong Fu Di, He Songqing. Research Progress of the pathogenesis of non -alcoholic fatty hepatitis

[2] zhou f, et al. UNEXPECTED RAPID Increase in the Burden of Nafld in China from 2008 to 2018: A Systematic Review and Meta‐analysis [J]. Hepatology 2019, 70 (4).

[3] Liu Xuejing, Wu Jian. Copy of the cancer of non-alcoholic fatty hepatitis [J]. Chinese liver dirt disease magazine, 2019 (3): 227-231. [J].

[4] Golden Tiger, Jiang Keqing, Zhong Fu brother, He Songqing. The research progress of the treatment of non-alcoholic fatty hepatitis [J]. Chinese experimental surgery magazine, 2021,38 (10): 2055-2060.

[5] Huang Yingshuo, Dong Ruihua, Youhong. Non-alcoholic fatty hepatitis clinical trials of new drugs and challenges [J]. Clinical hepatobiliary disease magazine, 2021,37 (08): 1948-1952.

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