Professor Dalian Polytechnic published the research results of pain blocking flexible electronic devices on Science

On July 1, the Department of Engineering Mechanics of Dalian Institute of Technology, Analysis of the Structure of Industrial Equipment Structure, National Key Laboratory, Dalian University of Technology Ningbo Research Institute Professor Xuan Zhaoqian (co -first author) and Professor JOHN A. Rogers, Northwestern University, Jonathan, Oregon University T. Reeder Assistant Professor's topic combination, published on Science entitled "Soft, BioresorBable Coolers for Reversible Conduction Block of Peripheral Nerves". The study invented a biological absorbable flexible micro -flow control device, which achieved neurotipular block through liquid vaporization and cooling, which can be used to replace opioid analgesic drugs to achieve an accurate pain effect of no damage. For the first time, the work shows the successful application of biological absorbable implantable micro -flexible coolers in neurotocoburosis pain, which has very important guiding significance for future pain management research based on flexible medical devices.

Pain is one of the important issues that need special attention clinically. Through local cooling to form reversible nerve blocks, it can not only achieve the effect of eliminating the pain on demand, but also to completely avoid taking opioids and other analgesics. Essence Traditional local cooling technology needs to use large medical equipment and implement it in specific environments. It is often difficult to achieve accurate cooling effects, and there are great limitations in practical applications.

Figure 1 Bio -based creature can absorb flexible coolers based on micro -flow body and accurate blocking nerves

In response to the challenging issues specially concerned about the above industry, the research team has designed a flexible, self -entangled (free suture), and biological absorbable peripheral nerve cooling micro -flow control equipment (Figure 1). Accurate and minimally invasive cooling effect. This flexible device integrates the micro -flow control system and the circuit system, which controls the flow rate and flow of the fluid in the micro -flow control system in the device. The precise and continuous cooling effect; distributed the magnesium line temperature sensor with a snake -like shape to the end of the device, and obtained temperature feedback through real -time changes through the sensor resistance. The mechanical design allows the device to form a self-curling structure. It can be closely attached to the nerve surface that needs to be cooled without suture and can form a good force-thermal interface. The device is composed of water-soluble materials. Solubble in the biomotoic fluids under the subcutaneous tissue within the prescribed time period. This avoids the pain caused by additional disassembly surgery to patients, and can well meet the patient's analgesic needs in the long period of time. Compared with existing technology and products, it has a significant advantage.

Figure 2 The finite element simulation and experiment of the cooling area

In the research work, the structure and temperature control optimization design was carried out based on structural mechanics and heat transfer analysis. The device also realized the precise non -destructive cooling of neural tissue, effectively blocking the pain of pain (Figure 2).

Figure 3 The experiment of cooling induced nerve block and analgesia

Related animal experiments (Figure 3) confirmed that the device can achieve low temperature regulation in a short time and can inhibit neurological activity well. Long -term observation shows that neural activity quickly returns to normal after re -warming and does not produce any side effects. The device can also provide excellent analgesic effects on demand for the animal model of free activity. According to the analysis of animal models, it is also found that the equipment cuff belt can still be closely contacted with nerve after 6 months of implantation, showing extremely superior mechanical properties. At the same time, biological experiments have also verified that the device has good biocompatibility and absorption.

Professor Xuan Zhaoqian joined the team of Professor Guo Xu in the Department of Engineering Mechanics of Dalian Institute of Technology in 2020. He successively selected national youth talents, Liaoning Province "Xingliao Yingcai Plan" youth top talent, and outstanding young scientific and technological talents in Dalian.

News source: Dalian University of Technology News Network

Edit: Hu Xiaomeng

School pair: Zhu Zhouqi Yu Jiawen

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