Chen Chen: Use nano -technology to improve the efficacy of tumor immune | Shining SDUER

Chen Chen, a graduate student of the 2018 school of pharmaceuticals, and Professor Jiang Xinyi. Published 7 SCI papers in professional high -level journals, including 5 SCI papers published in one/common work, including Nature Nanotechnology and other journals. The cumulative influence factor 81.5, obtained 3 national invention patents, participated in the National Natural Science Foundation of China 1 item. He has won the honor of Shandong University President's Award, Academic Award, National Scholarship, Excellent Graduate Models, and First Prize of Excellent Achievement of Graduate Students in Shandong Province.

During the doctoral degree, Chen Chen carried out the research of immunoaged accurate regulation drug interpretation strategies with the main line of immune response, and designed a series of multi -functional intelligent nano -drug systems to effectively improve the effect of tumor immunotherapy.

Discipline fusion, targeted anti -tumor

"After graduating from a master's degree in 2018

I took a break at home for two days and I entered the school in advance "

Accompanied by cicada, green leaf sands and sand

Chen Chen stepped into the Tuotuquan Campus on July 1st

Starting her journey of reading at Shan University

"Tumor"

A word that listens to people's bravery

Obviously removed tumors often "go back"

The recurrence of tumors often makes clinicians feel helpless

How to use pharmacy to combine immunology means

To overcome the recurrence of tumor surgery

The purpose of targeted therapy

This is Chen Chen's research direction

Traditional immune drugs have obvious effect on heat tumor treatment

But because of cold tumor

The response rate of immunohistochemical point inhibitors is low

Multiple drugs are often required for combined treatment

So as to play the role of coordinated efficiency

But there will be a problem of increased toxicity in the treatment of multiple drugs

Chen Chen's research joined the method of nanotechnology

Use nano -preparation to deliver a variety of drugs

Can achieve the effect of reducing drug reduction and efficiency and improving anti -tumor

For example, clinically

A vacuum cavity will be formed after brain tumor resection

Construct a type in the cavity

Injectable bionic nano -immune regulator

——The hydrogel ultra -structural delivery system

Not only can it be filled with the empty cavity after the operation

And can effectively play the role of immune regulation

At present, this technology has been successfully applied to

IDH1 mutant -type malignant cerebral gel tumor postoperative immunotherapy

The hydrogel system

On the one hand, it can increase the activation of T cells and gather in the brain

on the other hand

Actinable amino acid metabolism eliminates the inhibitory effect of TREG cells

Therefore, reshape thermal tumor killing immune micro -environment

Prevent the recurrence of postoperative gum tumor

The teacher quotes the way, from 0 to 1, from 1 to ∞

Pharmaceutical preparation is a study of drug preparation type

Basic theory, prescription design, production process, reasonable application

And the absorption, distribution, metabolism of drug preparations and drugs

Comprehensive technical science of the relationship between excretion relationships

Research content is wide and the discipline is cross

Talk about why

Multi -functional intelligent nano -drug system implementation mechanism

As the main research direction

Chen Chen said that his scientific research road benefits from

Instructor Professor Jiang Xinyi's guidance, encouragement and help

The mentor returns from abroad

Bring a lot of novel research perspectives

In a one -to -one communication with the instructor

Chen Chen's vision has been expanded greatly

Research interests further improvement

then

"As soon as I enrolled, I have determined the big research direction of immunotherapy."

Because immunotherapy is a hot spot in the current international research

Look at the literature and want to innovate

No matter how hard work

It seems that there are always previous generations who have thought or have done it

she knows

If you want to do a way alone

Only innovate from the source

After a lot of reading literature

Under the guidance of the mentor

Combined with the current problems that need to be solved clinically

Chen Chen has determined the main line with the procedure of immunization response

Carry out the research direction of immune precision regulation drug interpretation strategy

Although the analysis of the complex molecular network and the genetic panoramic diagram of the disease

Promote the development of immunotherapy

However, the treatment effect of immune drugs is still limited

Her goal is to use the means of pharmacy

Combining related knowledge such as immunology

To overcome this tumor treatment problem

I hope my research can bring the gospel to the treatment of tumor patients

The road is long, and the line is coming

Chen Chen's first scientific research article

Based on the scientific research ideas during the master's degree

During the doctoral period

Instructor "handle"

Instruct her to modify the article, modify the picture

Although the influence factor is not high

But this scientific research article achieved a breakthrough from 0 to 1

The joy of success

Inspiring Chen Chen on the road to scientific research is gone.

From the beginning of scientific research Xiaobai

After the feedback from the opinion of the review

You can see where the problem is and improve

Chen Chen said

This is due to the subtle influence of the instructor's positive mentality

"The instructor has led us since the beginning

Pay attention to the research dynamics of international academic frontier and well -known research group

Read high -quality literature

Whether it is a working day or a rest day

As long as it is sent to the mentor's article

The mentor will definitely feedback the suggestion for the first time "

It is this kind of trust, encouragement, and inspiration education

And the mentor's serious and rigorous, pursuit of perfect scientific research spirit

Affected Chen Chen's continuous pursuit of scientific research from 1 to ∞

Scientific research is not dotted, the future is available

The road to scientific research is often accompanied by bitterness

Experimental failure, submission are rejected, it is commonplace

For example, do experiments

Cells are like a naughty "naughty bag"

Although carefully taking care of the experimental results, the cells died unexpectedly the next day

Another example is to find ideas in the early stage of research

Chen Chen often follows the existing documents to do experiments

Sometimes I can do it for the first time

But I can't do it for the second time

Sometimes, scientific research papers start from submission

Every day, the dynamics of the manuscript "belly"

—— "Is the status of the article changed?"

"Is it positive or not active?"

Some people may ask:

Reading, experiment, and running data of day after day

Will it make people feel tired?

But in Chen Chen's eyes

This is full of infinite fun

she says

As long as you insist on the research direction you love in your heart

If you accumulate thin hair, you will succeed in the end

Read a foreign language literature from the beginning

It often takes two weeks

Basically glance at now

You can know the main research method of the literature

Research content, research conclusions, etc.

This is Chen Chen's growth and transformation

Stay up late to do experiments, stay up late and wait for the experiment results

The sweetness and bitterness in the process are often incredible

Only personally experienced

Only in order to really feel

Looking up at the stars of the night, the gentle evening wind blew

Have a pleasant sense of fulfilling

When encountering scientific research bottlenecks

Chen Chen likes to draw strength from the text

Occasionally watch some "chicken soup texts" of the right medicine

Psychological guidance and resolution for yourself

In addition, insist on exercise, skipping rope, rotating rings, running

It is also a magic weapon to release the pressure of scientific research

she says

There are hardships and fun on the road of scientific research

Better and music is the charm of scientific research

"Doing what is undergoing now, time will not live up to your efforts"

This is a message from Chen Chen to the younger brothers and sisters

With love for scientific research

He has developed medicine to help medicine and benefit patients' benevolence

Chen Chen said, after the doctor graduated

I will keep love and focus on myself

Continue to deepen the scientific research of immunotherapy

Material Source | Rong Media Center

Author | Li Lin

Figure | Interviewee provided

Edit | Ma Qianqian Yuan Yining Xu Kang

Editor in charge | Miao Liqun

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