Explore the mystery of biological macromolecules

Shi Yunyu is in office.

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Character business card

Shi Yunyu: Academician of the Chinese Academy of Sciences, biophysics and structural biologists, professor and doctoral supervisor of the University of Science and Technology of China. Born in Chongqing in April 1942, he was admitted to the Department of Biophysics of the University of Science and Technology in 1960. Since then, she has forged an inextricable bond with life science. Over the years, Shi Yunyu has always adhered to the first line of scientific research, using structural biology methods to study the molecular mechanism of gene expression regulation and cell fate, and achieve many innovative achievements, and contribute to the international biomagnetic resonance research in Chinese biomagnetic resonance.

With a clothing, a silver hair, in the office, Shi Yunyu hits the mouse, and the three -dimensional structure diagram of the protein jumps into the eye: "The world of biolis elements is full of unknown. We encountered many difficulties and challenges in the research process, but Don't give up lightly. "Shi Yunyu said.

The father’s words and teaching, what you see on the road of studying, let the seeds of scientific research report the seeds of the country rooted up.

Shi Yunyu has always had a dream of research! Whether he was leaning on his father at an early age, he listened to his colorful and colorful depiction of the physical world, or on the road of studying, and came into contact with the forefront of life science.

Shi Yunyu was born in the era of war. The experience of childcare and departure made her realize that her personal destiny was always closely linked to the destiny of the national nation. His father Shi Shiyuan is a PhD in physics directed by Mrs. Juri. After graduating, Shi Shiyuan, at the age of 25, returned to teach and became one of the pioneers of Chinese nuclear physics research and nuclear physics higher education. In Shi Yunyu's opinion, the spirit of scientific research reporting the country shows vividly on his father; his words and tutoring have also inspired Shi Yunyu's enthusiasm for scientific research.

With her love for natural science, in 1960, Shi Yunyu was admitted to the University of Science and Technology of China. At that time, biophysics was a new subject, and the education system was not yet mature. "Academician Bei Shizhen, then director of the Department of Biophysics of the University of Science and Technology of China, believes that the course settings should be 'four different", allowing students to play mathematics, physics, chemistry, and biological foundations. "Shi Yunyu said that it is a solid basic curriculum study to himself in the future for himself The scientific research work laid a solid foundation.

In the classroom, Qian Xuesen, Hua Luogeng, Yan Jici and other scholars gave everyone the period of class, letting her remember ... Shi Yueyu said: "I can feel the strong patriotic feelings of the older generation of scientists at close range, how are it fortunate!" In the auditorium Everyone is close to a black and white TV to win the championship of the Chinese athletes to win the World Table Tennis Championship. I have made up my mind to contribute to the construction of the motherland with my own scientific research results. "

After graduating from college, Shi Yunyu was assigned to work at the TCM Research Institute of the Ministry of Health; in 1970, she returned to the Chinese University of Science and Technology to teach. It didn't take long to move from Beijing to Hefei, Anhui.

Shi Yunyu assumed the task of relocating the equipment of the south. She and her colleagues moved to the stations filled with equipment from the teaching building to Beijing, and after reaching Hefei, they moved the box from the station to the teaching building ...

Earlier engaged in the study of macromolecular computer molecular dynamics simulation; leading the creation of the Structure Biology Key Laboratory of the Chinese Academy of Sciences

The relocation of the University of Science and Technology of China, the loss of scientific research equipment, and weak teaching forces ... "Fortunately, the school later took a series of new measures to gradually go to the right track." Shi Yunyu said that the school provided the young teachers with the opportunity to send abroad to study abroad. It is the first young teacher who passed the Ministry of Education's examination. She went abroad for study twice, engaged in computing biology research and biomagnetic resonance spectrum studies, and learned the theory and experimental methods of biological macromolecules and two -dimensional nuclear -magnetic resonance spectrum to study the structure and function of biomolecules. Shi Yunyu said: "The experience of overseas learning has pioneered my scientific research field, and also urged me to learn more hard."

In the 1970s, Shi Yunyu and his colleagues urgently wanted to keep up with the footsteps of the international academic community and conducted cutting -edge research on biological macromolecules in the University of Science and Technology, but lack of funds and instruments. In order to quickly promote the project, Shi Yunyu and his colleagues all ran through the library in Shanghai, checked literature, flip the information, racked their brains, and boiled for two weeks before writing the application of the "National High -tech Research and Development Plan".

At that time, the Department of Biology Department of the University of Science and Technology was selected. Shi Yunyu was responsible for the "new technical research of protein molecular design". Since then, she has been engaged in research on the molecular dynamics simulation of macromolecules and has become one of the founders in this field. The "Computer Simulation of Biomolecular Structure and Dynamic" led by Shi Yunyu won the second prize of the 1996 Chinese Academy of Sciences Natural Science Award and the third prize of the National Natural Science Award in 1999.

In the early 1990s, Shi Yunyu's laboratory was supported by the Chinese Academy of Sciences. The first 500 MPAR nuclear magnetic resonance spectrometer that can be used as a large -molecule solution structure can be used as a biomolecular solution structure. It is firm: "Scientific research must concentrate on the ambition, tolerate loneliness, and stand the folding." The research team led by Shi Yunyu analyzed the solution structure of the series of important protein, and studied revealing protein interaction and its functional significance. She also led the creation of a key laboratory of the Structure Biology of the Chinese Academy of Sciences, and later became an important part of the National Research Center of Hefei Micro -scale Material Science. Do popular science for primary and secondary school students, talk about basic lessons for undergraduates, and cultivate more young scientific research talents

Shou County, Anhui, No. 1 Middle School. On the stage, Shi Yunyu held the microphone to tell his own experience and life science knowledge; on the stage, the students concentrated, and were deeply attracted by the biological macromolecular world she described. From the inspiration of scientific interests to the choice of scientific research, from the solid foundation to the enthusiasm of the country, in an hour and a half, Shi Yunyu sprinkled the seeds of science in the children's heart ...

Although it has been eighty years old, Shi Yunyu has many times in primary and secondary schools to conduct science lectures for students. "I have been in contact with scientific knowledge since I was a child, which inspired my curiosity and embarked on the road of scientific research; I also wanted to pass this enthusiasm to the children." Shi Yunyu hopes to open a scientific window for the children.

Shi Yunyu remembers: In 2019, in the Central Primary School of Massachusetts, Macheng, Macheng, she told the children in the Dabie Mountains a science popularization course on "hemoglobin and hemoglobin disease". The eyes of the classmates are full of thirst for scientific knowledge and deeply moved her, so she more and more likes to walk out of campus and go to the mountains ...

At the School of Life Sciences of the University of Science and Technology, in order to strengthen the basic education of undergraduate students, Shi Yaoyu insisted on taking ordinary biology courses for freshmen for many years. Shi Yunyu said that basic courses are critical for cross -disciplines. "Teaching is the duty of teachers. I want to cultivate more talents for scientific causes." As the first dean of the School of Life Sciences of the University of Science and Technology, she and her colleagues took the lead in establishing a structured and computing biology teaching system in Structural Biology. Experts from the Institute of Biophysics of the Chinese Academy of Sciences were also specially invited to teach students for students to train a number of young discipline leaders working in cross -disciplinary fields such as computing biology and structural biology.

Today, her silver hair is still in a hurry to work in the laboratory every day. In school, when I encountered Shi Yunyu, the students always called her "Grandma Shi". Right now, "Grandma Shi" has begun to engage in the study of the protein structure of aging and degenerative diseases and the molecular cell mechanism of the disease. In addition, she is actively promoting the research of artificial intelligence and biomedicine. She believes that every new field has a lot of knowledge to learn. The joy of climbing is not only the moment when it reaches the top of the mountain, but also in the process of climbing.

■ Reporter Notes

Study never stops, only lifelong learning

During the interview, Shi Yunyu was very interesting to mention the cutting -edge development of life science ... At the age of 80, she was also willing to learn with young people while cultivating scientific research talents. In Shi Yunyu's view, being able to explore the mystery of the macromolecular world with students is both happy and fulfilling. Young people are always faster to learn new things. When she doesn't understand, she can experience the taste of being a student.

Life science is closely related to the health, medicine, and ecology, and the world of life is full of many unsolved scientific problems. For Shi Yunyu, research never stops, and only for life. It is countless scientists like her, always studying enthusiasm and constantly climbing up, so that scientific research has glowed endlessly ...

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