Witness to be extraordinary | Realize more breakthroughs from 0 to 1 "

Author:Xiamen University Time:2022.09.22

Editor

Since the 18th National Congress of the Communist Party of China, my country's higher education reform and development have achieved remarkable results. Xiamen University has worked hard and bravely, and wrote a wonderful "Xiamen University Chapter" in the history of the development of higher education in China.

To this end, the Propaganda Department of the Party Committee launched the "Ten Years of Welcome to the Twenty Xiamen University" columns. This issue is the fourth issue. We have launched a basic research chapter. Through the stories of three scientific research teams, we will show you the development of basic research in Xiamen University in the past decade. Next, we will also launch a transformation of scientific and technological achievements, so that more scientists in Mansion University will tell the story of the decade of the decade of the development of the national strategy and regional economic development of the Communist Party of China.

"How long does it take to study a question?"

Maybe it is one day, maybe one year, maybe ten years, or even longer.

The researchers engaged in basic research in Xiamen University chose to answer this question from a longer time dimension: they "ten years like one day", with the spirit of "nailing", adhered to the scientific research in their respective fields; they "ten years in ten years "Mo a sword", with the strength of "sitting hot and cold bench", aiming at the forefront of the world science and technology, climbing the peak of scientific research.

Innovation -driven development, primitive innovation is the source. In the past ten years, Xiamen University has continued to increase basic research, continuously improved its original innovation capabilities, and high -level scientific research results have emerged successively.

Today, we approach the three scientific research teams together. From the stories of their years of research, we feel that the adults of Xiamen are determined to realize the persistence and efforts from the "0" to "1" breakthrough.

Talk to micro organisms, diagnosis of global climate

△ Academician Jiao Nianzhi in the process of marine carbon exchange and biochemistry

The theme report was made at the starting meeting of the Basic Science Center

In May of this year, more than ten academicians and experts witnessed the official launch of the first national basic science center in China- "Marine Carbon Exchange and Biological Geochemical Process". Academician Jiao Nianzhi.

In 2020, my country clearly put forward the strategic goal of "carbon neutrality". To achieve this goal, we cannot just rely on emission reduction, but also explore the new ways of "decompression" by increasing exchange for emission reduction to ensure economic development. The ocean is the largest active carbon library on the earth, which should play an important role in dealing with climate change, but this is a blank in the IPCC list. How to achieve the "negative emissions" of the ocean, that is, "effectively increasing" is an urgent task in front of scientists.

Earlier, in the ecological laws of studying good oxygen and oxygen -producing light and heterogeneous bacteria, in the face of the confusion of existing theory and actual situation, he persisted in digging out "clues" from the mixed phenomenon, and eventually internationally For the first time, the "micro biological carbon pump (MCP)" carbon storage theory was proposed. The theory has opened up a new field of marine carbon exchange research, and has been commented by the American "Science" magazine as "behind the scenes of the huge carbon storage."

The MCP theory refers to the miniature organisms with countless individuals in the ocean, but they can turn activity organic carbon into inert organic carbon to keep carbon in the ocean for a long time, that is, "micro biological carbon pump", that is, the "micro biological carbon pump" " Carbon storage effect.

Over the years, Jiao Nianzhi led his team and has been dealing with these "invisible protagonists" in these oceans.

"You can't run with others, you can't take the tomorrow of others to dress us up yesterday." In Jiao Nianzhi, the word "innovation" is especially important for scientific researchers. Based on the MCP theory, in the past ten years, the Jiao Nianzhi team has continuously enriched and deepened its own theoretical system through a large number of investigations, evidence collection, and comparison to promote scientific research and innovation -

In 2015, the "miniature creature's role in marine carbon repository and climate change" project won the second prize of the National Natural Science Science. In 2019, the theory of "marine micro -biochemical pumps" and related remittance measures were included in the special report of IPCC climate change, marking that the breeding environment that my country has been criticized by foreign countries can be gorgeous to become an ideal place for the implementation of marine discharge, and enhance that my country in the world in the world in the world in the world The right to speak in climate negotiation. In 2020, focusing on the theme of "carbon neutralization", with "negative ocean emissions", Xiamen University established a carbon neutralization and innovation research center. In 2021, the team published an article in the "Science" sub -publication that the "lost carbon exchange" that had been wrongly judged in the past provided technical support for accurately judging the carbon exchange and the achievement of carbon neutrality. In 2022, 78 universities and scientific institutes of 33 countries, including Xiamen University, and the International Science Program of ONCE Emissions (ONCE) initiated under the leadership of Jiao Nianzhi, were included in the "UN Ocean Science Promoting Sustainable Sustainable Development for ten years. "Action for Action ...

Adhering to the scientific research principles of "open thinking and rigorous verification", the Jiao Nianzhi team has always focused on the theme of "marine carbon cycle", carried out all -chain research in a multi -disciplinary cross, and continuously wrote new marine discoveries, contributed to Xiamen's power to actively respond to climate change. Essence

Practicing "the most beautiful artwork in your life"

△ Academician Lin Shengcai is explaining the glucose path model

The two -meta and dual -dual -dual -dual -dual -dual -dual -dual -dual -dual -dual -dual -dual -dual -dual drugs are commonly used for the treatment of type 2 diabetes. However, for a long time, its molecular target has not been discovered, which greatly limits people's application of it.

Until February of this year, Academician Lin Shengcai's team of the School of Life Sciences "fished" the answer.

As early as 2016, the results released by the team showed that the two -metal dual -dual -dual -dual -dual -dual -dual -dual -dual -bodied way to activate AMPK was activated by a channel called iconic messenger pathway when the body induction of hunger and blood sugar decreased. "The research at that time was equivalent to tracking the thief into the building, but I didn't know which room he was in." Lin Shengcai explained his image. Based on the above research direction, the team has been explored for more than five years. They use the two -seal "fish hook" and "fishing rods", and more than 2,000 "potential goals" are caught from the cells. Finally, after the filtering and verification one by one, the molecular target of the dual -two dual -dual -dual -dual -dual -dual -dual -dual -dual -dual -dual -dual -dual -dual -puppets confirmed that the enzyme -solid pathway was the correct path for the dual -dual -to -AMPK to activate AMPK. This study provides new ideas for the treatment of diabetes, and even the research and development and application of anti -tumor and anti -aging drugs, and the results have been successfully published in the world's top academic journal "Nature" magazine.

In the past ten years, Lin Shengcai team has deeply cultivated the field of metabolic biology and has continuously made new breakthroughs. In 2012, a molecular mechanism of cell autophaorus was revealed in the top international academic journal "Science". In 2017, the molecular mechanism of cell induction of glucose and regulating metabolism was stated in "Nature" in 2017. "Star Medicine" dual -dual target ... They are committed to analyzing the "password of life".

"Each protein has 10,000 functions." This is the most common sentence of Lin Shengcai. This philosophical mantra has become the enlightenment of many students in the research team into the scientific research field. Dr. Qu Qi said with a smile: "I couldn't understand at first, but after doing a few years of research with the teachers, it seemed that it was more and more able to appreciate it."

Lin Shengcai's laboratory is not large, but everyone is in a hurry and shuttles in different experimental desks. In the laboratory corridor, the "glucose perception path model" found by the team was attached to a conspicuous place. When someone comes to visit, Lin Shengcai often brings it here to explain. Pointing at this picture, Lin Shengcai said, "This is the most beautiful artwork in my life."

7 -year long -distance running, reproduce the "surprise" of Fullene

△ Academician Xie Suyuan guides students in the laboratory

In 2015, doctoral student Zheng Jianwei encountered an embarrassing situation -he got a nearly "perfect" original data in the experiment, but this result could not be repeated.

Just a few days ago, Professor Xie Suyuan of the School of Chemistry and Chemical Engineering gave Professor Yuan Youzhu in the corridor, Professor Yuan Youzhu, and asked him to give students experiments to test whether Fullene could promote the efficient preparation of ethylene glycol. The students who have received this task are Zheng Jianwei.

At that time, Fullene was extremely rare and the price was comparable to gold. Zheng Jianwei, who was strong in execution, was relieved, and quickly made a surprising result -the synthetic gas ethylene glycol that had to be achieved in a high -pressure environment was realized under normal pressure. Ethylene glycol is an important raw material for making daily necessities such as polyester, plastic, automotive antifreeze, and is closely related to social people's livelihood. If you can achieve ethylene glycol under normal pressure, it will be a major breakthrough.

But when everyone was excited to repeat the experiment, they found that how could they not reproduce the results. "Where did something go wrong?"

In order to understand this puzzle, three generations of graduate students and six subject combinations were relayed, and a seven -year scientific research "long -distance running" was opened. In seven years, many episodes have occurred. According to the students participating in the study, once, the original 1,000 -hour experiments were scheduled to be 960 hours, and the equipment suddenly broke. Everyone had to restart the experiment again. The sound of the machine has been repeated in the cold laboratory, and the sound of the machine has been repeated. The experiment lasted from the summer vacation of 2020 to the Spring Festival in 2021.

Fortunately, the puzzle was announced after seven years. They found that the core of the original technology was to compound Fullene and copper catalysts, "we now call it an electronic buffer effect," Yuan Youzhu said.

In April this year, the relevant research results were published in Science. On the eve of the thesis, Phillip D. Szuromi, the deputy editor -in -chief of the "Science" magazine who reviewed them, sent an e -mail, writing: "Thanks to Fullene, continue to maintain scientific surprises!"

From the discovery of the principles of "tension release" and "local aroma" to stabilize the new type of Fullene, to the invention of multi -stage combustion synthesis method to prepare a variety of Fullene and its derivatives, to the application of Fullene to the realization of ethyl Diols often suppressed ... Over the years, Xie Suyuan's team has always cultivated the chemical field of clusters, facing the needs of social industries, and continuously breaking through the "comfort circle" of Fullene research.

Interview notes

A signal molecule in small cells is so large that the climate change that affects the world ... In the past ten years, many scientific research areas have been active in the tech workers of Xiamen University.

"What is the most important thing to study? Thinking and innovation." "To speak by data." "Numerous scientific researchers produced countless Zhang 'paper'. In a simple but deep words, it conveys the scientific spirit of scientific and technological workers of the Basilica University of China.

Ten years long. In the past ten years, Xiamen University has continuously deepened the reform of the scientific and technological evaluation system, actively carried out international scientific and technological cooperation and exchanges, accelerated the construction of major innovation platforms, vigorously cultivated scientific and technological innovation talents, and continuously promoted high -level scientific and technological independence and self -reliance. Academician Tanaka Group developed a portable Raman spectrum fast detection system. Academician Sun Shigang team built the first international infrared free electronic laser reflection absorption spectrum experimental line. Academician Dai Minhan team and domestic and foreign partners have comprehensively summarized the global offshore carbon source exchange pattern and control process ... A large number of original scientific research results have emerged. Ten years are also short. The years are changing, but the original intention of the tech workers at Xiamen University has not changed. Sitting on the cold bench and suffering hard work, they held a "pen" of innovation, and constantly painted the science and technology painting scroll.

For ten years

Scientific research project

——The accumulated funding for nearly 11 billion yuan, an average annual growth rate of 13.74%, an increase of nearly 200%in ten years. The average annual growth rate of horizontal projects was 15.15%, and the annual growth rate of the average annual growth rate of vertical projects was 12.05%.

——The cumulative responsibility for undertaking 3199 National Natural Science Foundation of China and 133 projects of the Ministry of Science and Technology. Cumulative 58 major scientific research projects (the amount of the project is ≥ 10 million).

Scientific research platform

——The cumulative 10 new national platforms, 6 ministerial platforms, and 67 provincial platforms. At present, our school has 4 national key laboratory platforms, 1 national engineering laboratory, 1 National Engineering Technology Research Center, 5 National Local Joint Engineering Laboratory (Research Center), and two national -level collaborative innovation centers (lead) , 1 national production and education integration innovation platform, one national wild scientific observation research station, and 2 Fujian Innovation Laboratory.

Talent team

——The new academician (full -time) of the two academicians (full -time).

——The new National Natural Science Foundation of China 2.

——It 7 innovation research groups for the new National Natural Science Foundation.

——In 36 National Outstanding Youth Science Fund and 67 outstanding youth science funds.

Honor award

——In 7 National Natural Science Science Awards.

——In 30 first prizes at the provincial and ministerial level.

——En 3 people won the He Liang He Li Science and Technology Award.

——In the National Innovation Employment Prize.

——In 7 China Patent Awards.

——An 3 people won the Chinese Youth Science and Technology Award.

—— 5 people won the scientific exploration award.

——In 1 advanced collective of the national anti -new crown pneumonia epidemic.

Scientific research

——The a total of nearly 300 papers in Nature, Science, Cell, and its sub -journals, including 20 articles of Nature, Science, and Cell.

——The domestic authorized patents 6055 and 147 internationally authorized patents. In the past ten years, the number of domestic patents has increased by 170%. In 2020, our school successfully selected the first batch of "National Intellectual Property Demonstration College".

There are hundreds of students' calls.

Publish heavy! Xiamen University 2023 Master's Graduate Admissions Chapter