The academic papers of Zhengzhou University as a cover article published on Science!

Recently, the Henan Provincial Academy of Medical Sciences and the Huada Academy of Medical Sciences and Washinga University have made breakthrough progress in the regeneration of the brain. Yang Yunzhi, a graduate student of the college 2020, as the first author and the 2019 Master Graduate, Jiang Yujia, as a co-author, published a Single-Cell Stereo-Seq Reveals Involution in Axolotl Brain Regent PRAINRINRAINRAINRAINRAINRAINRANRANRAINRAINRANRANRANRAINRAINERINERAINERAINERINERITI or such as. Thesis, as a cover article. Zhengzhou University Henan Provincial Academy of Pharmaceutical Sciences and the Chinese Academy of Medicine were the first author of the joint author.

This paper is a cover article of Science Magazine

At this point, the college has published academic articles in international journals such as CELL (Cell "), Nature (" Nature "), and Science (" Science ") as a common communication or a common work.

This study is based on the Huada gene space enhancement resolution sequencing technology (STEREO-seq), and builds the world's first (Ambystema Mexicanum) brain development and regeneration space-time cell map. This is also the world's first brain regeneration Time and space spectrum reveals how brain injury is healed.

谱 Brain regeneration time and space map

The Mexican blunt mouth used in the study can regenerate damaged subsidiaries and multiple internal organs, including the brain, so scientists are used as important model creatures to study recycling related problems. Two students' research teams first build a group of spatial transcription group data covering six development stages and seven damage -induced regeneration stages to determine 33 types of cell types and 28 cells participating in regeneration in the development process. Types, including different types of excitement neurons and inhibitory neurons, as well as several subtypes of Ependymoglia Cell. The molecular characteristics of various neurons and dynamic changes in spatial distribution were displayed, and it was found that the brain has specialized neurotic stem cell subtypes with spatial regional characteristics since the youth.

In order to study the regeneration process after brain injury, the research team had mechanical damage surgery of the cortex area of ​​the brain, and used the time and space group to learn the 2nd, 5, 10, 15, 20, 30, and 60 days after the injury. The technical STEREO-SEQ "takes photos" of the brain sample, obtains the brain regeneration atlas of each time point, and completes the process of the brain from damage to the completion of regeneration repair. By comparing the "photo" and wound status in the process of 7 times, the research team found that the wound area appeared in the early days of damage. Converted after being injured and stimulated, and in the subsequent regeneration process, a neuron was born to fill the lack of neurons that were missing. In addition, although the wound was gradually filled by freshmen in the early days of repair, it was not until the 60th day after the injury, the "photo" showed that the cell type and spatial distribution of the damage area returned to the state of the unmotled side.

Yang Yunzhi, a graduate student at level 2020 at the University of China at the University of Huada from Zhengzhou University

Jiang Yujia, 2019 Graduate Student Student from the University of Huada Genes at Zhengzhou University

At the same time, the research team also observed that the regeneration of Mexico's brain has shown a similar nerve occurrence pattern in terms of molecular -level joint reactions and potential cytotore conversion, which indicates that the brain regenerates the development process.

Through research, the key nerve stem cell sub -group in the brain regeneration process depicts the process of reconstructing the injury neurons in such stem cell sub -groups. The brain structure and development process provides a new direction for the regenerative medical research and treatment of the nervous system.

This research is of great significance to understand the evolution of the brain regeneration, amphibious animal brain structure, and the evolution of the brain structure. It provides a new direction for finding effective clinical treatment methods and promoting self -repair and regeneration of human organizations and organs. Provide valuable data resources for species evolution research. Researchers will explore the development and regeneration process of more organs and more species through multiple groups of technical technologies in time and space, find key regulation mechanisms in the process of regeneration, and help the development of human regeneration medicine.

Introduction

Zhengzhou University Huada Genes is a secondary college of Zhengzhou University, one of the nineteen scientific research platforms. Relying on the construction and operation of the Henan Provincial Academy of Pharmaceutical Sciences, it will be signed by Zhengzhou University and Shenzhen Huada Gene Technology Co., Ltd. Research college built in cooperation. Recruiting master's and doctoral students, now 133 graduate students. Deliven the relevant research of precision medicine and life sciences, build an international and high -level research college, build an international first -class scientific research platform, innovation platform and technology radiation platform, and cultivate high -level innovation -top talents in scientific research and industries in the field of biomedicine.

- END -