Li Shaowei: Healthy "Umbrella" who builds an immune barrier 丨 The most beautiful science and technology worker in Fujian Province in 2022 (1)

For more than 20 years,

He is engaged in genetic engineering vaccine

And structural vaccine, etc.

On the road of application basic research

Tire tirelessly, ask for a cable;

He climbed the peak with the team,

Breaking international technical blockade,

Develop a number of "the first" and "the first domestic";

He developed as a core personnel

Hepatitis, AIDS

And new coronary virus

New drugs such as a series of diagnostic kits,

Provides strong technical support for infectious disease prevention and control.

He is the School of Life Sciences, Xiamen University

Professor of the School of Public Health

Li Shaowei

Independent R & D Monopoly

Help HIV diagnosis and then improve quality

In 1998, Li Shaowei began to study doctoral students at Xiamen University, mainly developing the development of HIV diagnostic kits. At that time, the third -generation HIV diagnostic reagent in my country could only rely on imports. "The entire diagnostic reagent field, basically good reagents are foreign, and the third -generation HIV diagnostic reagents are all foreign." Be sure to break this "card neck" problem.

He played the director of learning in biochemistry, working almost 16 hours a day, and after a large number of experimental exploration, he found the method of soluble high -active HIV membrane protein, and finally overcome the development of the third -generation HIV diagnostic reagent. The technical difficulties of the active raw materials required.

Li Shaowei introduced that if diagnostic reagents are compared to cars, these raw materials are equivalent to "car engines." It is precisely because these raw materials have long been monopolized by foreign companies that my country can only rely on imports.

As a result, he and his team partners successfully developed the first third -generation dual antigen sandwich diagnostic reagent. After the listing of this domestic kit, the market price of the third -generation HIV diagnostic reagent at that time was reduced to one -tenth of the previous one -tenth, which produced major social and economic benefits. In 2001, this scientific research achieved the second prize of national scientific and technological progress. "This is the first big result we have obtained." Li Shaowei said.

Since then, he and his team partners have further developed the domestic fourth -generation HIV diagnostic reagent, and once again lead the upgrade of domestic HIV diagnostic reagents. The two generations of domestic HIV diagnostic reagents have been the first in the domestic market for 19 consecutive years. They are sold to more than 40 countries including Germany, Britain, and France, with a total usage of more than 600 million people. The world's first HIV urine antibody self -test that can be used for self -detection of individual self -detection in 10 years is listed in 2019, which will help increase the willingness to actively test the risk -up people and be selected as "major progress in China in 2019".

Another way of seeking innovation

Make pentalitis prevention

In 2005, Li Shaowei began to serve as the leader of the vaccine group of the national infectious disease diagnostic reagent and vaccine engineering technology research center, responsible for the research and transformation of genetic engineering vaccines.

Li Shaowei found in the previous development of HIV testing kits that compared with the real nuclear biological expression system used by the previously listed genetic engineering vaccine, the cost of the proactive system is low, the bacteria are easy to cultivate, and the growth rate is fast. Therefore, he began to imagine the development of a new path -the research on the pental vaccine using the E. coli eukaryotic system.

I do n’t know how many days and nights, and finally, as a key research personnel, their team first developed a new generation of new -generation Hepatitis diagnostic kits. These achievements were authorized by invention patents in 10 countries and regions. Patent gold award. Products dominate the domestic market, with market share exceeding 80%, exporting to more than 20 countries including Britain, France, and Dutch. Then, on this basis, a comprehensive platform for R & D of E. coli vaccine based on virus -like particles was established, and in 2015, it won the collective award of Hong Kong Qiuye's outstanding technology achievement.

On October 27, 2012, the world's only pentatheal vaccine developed by the team was listed in China and was approved to be listed in Pakistan in 2020. But more importantly, it is precisely because of their research and development results that the pentagin has become the 29th prevention of diseases in human history and won praise from the academic and industry circles at home and abroad. The achievement exhibition has won the second prize of the National Technology Invention, and the Asian Best Technology Innovation Award.

It is difficult to fill the blank while fighting over

Contribution to the elimination of cervical cancer

Human nipple virus (HPV) vaccine is commonly known as cervical cancer vaccine. Before Li Shaowei's team independently developed domestic cervical cancer vaccines, my country has long relied on imports for a long time. The price of imported cervical cancer vaccines is high and the supply is insufficient, which is difficult to meet the needs of domestic age groups.

In 2002, Li Shaowei's team began research on cervical cancer vaccine. "To break the patent barriers to develop vaccines in the United States and the United States, the team must use methods that are different from the UK and the United States as the use of real nuclear cells to perform vaccines in order to surpass the basic system of existing patent establishment." Li Shaowei introduced.

The scientific research team decided to use E. coli, such as E. coli, to express, which is a new type of vaccine technology that is different from foreign countries. Twenty years ago, the concept of using E. coli as Cervical Cancer was almost blank in scientific research. In the process of establishing the system, the research team was questioned and denied by the domestic and foreign industry.

The experimental data is not ideal, the problem of a certain vaccine preparation lasts for 3 years, and the year -end report has been crying because of delayed breakthrough progress. "Everyone persisted with faith and solved various technical problems step by step." This is this road that is considered "unprepared" by the outside world. Many white hair. In the end, they adopted the original vaccine development technology system to break the international technical blockade. The first domestic cervical cancer vaccine was born in Xiamen. Thanks to the advantages of low E. coli cost, fast production speed, and high yield, the price of domestic cervical cancer vaccines is less than half of the imported vaccine. This vaccine was launched in December 2019. The scope of vaccination at the end of 2020 covers the entire country of my country. In October 2021, it passed the PQ certification of the World Health Organization. Essence The vaccine is the first cervical cancer vaccine that has completely independent intellectual property rights and obtained internationally recognized by developing countries.

In addition, the nine -valent cervical cancer vaccine developed in 2020 opened the phase III clinical trial in 2020; the 20 -valent cervical cancer vaccine has completed the concept verification and is conducting pre -clinical research ... These results marked the core of the cervical cancer vaccine developed independently in my country The technical system has become mature, and Li Shaowei's scientific research team has contributed China's power to accelerating the elimination of cervical cancer plans worldwide.

In 2017, he was selected for the 2016 global TOP 20 transformation researcher selected by the well -known magazine "Nature • Biotechnology". "Best Thesis of the Year"; in 2021, he won the 23rd Chinese Science and Technology Submission to the Achievement Award of Outstanding Youth Award ... This honor and award, which stems from his "bench for ten years cold" His persistence and determination stems from his love and persistence in professionalism.

Attentive scientific research, helping my country ’s independent research and development of vaccines on the battlefield of the owner of the international vaccine industry, and realizing that from follow -up, and running to lead, he is still on the road.

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