Chen Gen: New light immunotherapy, bringing a new dawn of cancer

Wen | Chen Gen

Tumor stem cells are the key to the formation of cancer formation, growth, metastasis, and drug resistance. It can be said that it is the "motivation" to maintain cancer. As one of the most common malignant tumors in the nervous system, the clinical manifestations of glioblastoma are extremely invasive. Its recurrence rate is extremely high and the mortality rate is extremely high. Generally, the 5 -year survival rate of patients does not exceed 5%, which is one of the most difficult tumors in neurosurgery therapy.

Globe female cytoma is located on the central nervous system and is formed in the support tissue of spinal cord and brain. Due to its very sensitive growth position, it is difficult to surgery and it is easy to leave residual tumors. This means that cancer may recur at any time. In addition, immunosuppressive cells in the tumor microe environmental (TME) also make immunotherapy unable to play a role. Therefore, the surgical method of adhesive maternal cytoma is urgent in clinical treatment.

To solve this problem, recently, a research team from Europe jointly developed a new type of light immunotherapy. This therapy can not only accurately identify and clear the glue female celloma in the brain, but also use light to transform the immunosuppressive environment into an environment with immunoaged attacks, which brings new hope to the treatment of cancer patients.

Optical immunotherapy is a treatment method of photocrading. The specific mechanism of action is to enter drugs by dripping to the patient's body, which contains antibodies that can be attached to cancer cells and chemicals that react to light. Since then, patients will have a chemical reaction, and cancer cells will be automatically destroyed.

In the new therapy, researchers combine EGFR specific affinity molecules (ZEGFR: 03115) with a fluorescent molecular IR700 used for surgery to form a coupling Zegfr: 03115-IR700. After that, the light was illuminated on the puppet couplet to light up the light sensitrant to highlight the micro -area of ​​the tumor in the brain, and when switching to the near -infrared light, it played a anti -tumor activity to kill tumor cells.

The scan results show that this new treatment method can effectively "light up" the smallest cancer cells and help doctors to accurately locate them. It is worth mentioning that the therapy also triggered an immune response, which allows it to reduce the probability of recurrence of colloidal cytoma surgery when targeting cancer cells in the future.

Compared with existing technologies, the new photochaosium immunotherapy can help surgeons remove more tumors and kill the remaining cells within a few minutes after surgery. In the future, it may bring the innovation of cancer treatment technology.

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