Xu Xun, Shenzhen Institute of Life Sciences in Shenzhen: In order to unveil the "Life Password"

★ 2022 Guangdong "Most Beautiful Science and Technology Workers" series report

★ Strong country, me

Gene is known as "the password of life". It supports the basic structure and function of life, and also stores all the information of life breeding, growth, apoptosis and other information, which is continued by generation and one generation. At the beginning of this century, the completion of the human genome plan brought a lot of changes to the field of life and health. In the past 20 years, human beings have also been deepened by human beings. In addition, in -depth exploration of genes, the importance of agriculture, animal husbandry development, and protecting biological diversity cannot be ignored.

In Shenzhen, there is my country's first national comprehensive gene library. Fighting in this gene library, scientific researchers have devoted themselves to discuss the "password of life" and practice the mission of "genetic technology to benefit humans". Among them, a leading figure, Xu Xun, dean of the Shenzhen Huada Life Sciences Research Institute, won 2022 Guangdong "Most Beautiful Science and Technology Workers" and Shenzhen "the most beautiful science and technology workers" this year's "National Science and Technology Worker Day" "Honor title.

【Exploration Road】

Growing up with our genetic technology

"I firmly believe that genetic technology can better benefit human beings ..." Xu Xun, who has taken root in the field of life science for 15 years, has witnessed the development of my country's genetic technology from scratch, from "following" to "leading". He is a witness and participant, and gradually becomes a leader.

In these years, the project he has participated in is hundreds of large and small. In many scientific research tasks, in 2021, the task of reaching the depth of the sea was one of his most unforgettable tasks in recent years. At that time, 17 scientific and technological personnel from 7 units across the country followed the "Struggler" manned submersible with the "Exploration One" scientific test ship to complete the abyss of the Mariana Trench. Xu Xun became one of the 17 scientific and technological personnel and participated in the exploration task. The task is to compare the different abyss environment, geology and life, etc. to provide valuable data and samples.

According to his memories, the entire scientific examination experienced 53 days of exploration journey. This time, the sea conditions are not very good. During the scientific research process, the maximum gust of 24KN has been experienced. In the process, not only must it overcome the physiological discomfort of seasickness, but also the preparations and inspections before and after diving. He reached a depth of nearly 10,000 meters when he dived. The whole process was 12 hours. It took nearly 6 hours to stay in the abyss of 10,000 meters. After returning to the ship, he had to deal with the collected samples in time. Due to the limited experimental conditions on the ship, usually Sample treatment should be carried out in a small 4 ℃ cold storage, and it is often treated until the middle of the night.

Later, the scientists who went to the sea scientific research announced the launch of the "Mariana Trench Ecological Environment Scientific Research Plan", inviting researchers at home and abroad to work together to attack the formation and evolution of the deep -sea scientific system, the origin and environmental adaptation of life, the biological diversity and the climate of the climate Major scientific issues such as changes. "Based on this plan, the scientific research team I led will further digitize the biodiversity resources of global abyss, further explain the scientific issues of the origin of life and extreme environment adaptation technology. At the same time, these genetic resources will also help industrialization applications." After the scientific research task was completed, Xu Xun told reporters in an excitement in an interview.

【The Road to Breakfast】

Realize the research and development tool autonomous controllable

Due to the many years of cultivation in the field of genetic research, Xu Xun deeply realized that the core tool is the basis of scientific and technological innovation. To establish a long -term advantage of scientific and technological innovation, we must first completely change the core tools in the field of cutting -edge science and technology. Xu Xun led the team to eliminate all difficulties to successfully acquire the US CG company and innovate based on the digestion, absorption of its core technology, and successfully developed a desktop sequencer with completely independent intellectual property rights. Require. Filled the blank situation of my country's domestic commercial sequencers, and also broke the situation that high -end sequencing technology relies on imports for a long time.

In addition to the complete autonomous and controllable sequencer, Xu Xun also led the team to develop the first single-cell chromatin structure and the multi-group of the transcription group SCCAT-SEQ, and further completed the first domestic single-cell micro-current control system Development of DNBLAB C4.

At the same time, based on the independent DNA nano-ball sequencing chip, Huada also developed STEREO-SEQ technology that can realize the time and space group of centimeter-level vision and nano-level resolution to lead the international level. The time and space group is another major breakthrough in life science research tools after microscope and sequencing technology, which will provide underlying tools for re -cognitive organ structure, life development, species evolution, and defining human diseases.

【Road to Harvest】

Continuous output high -level research results

In addition to tools and technology, Xu Xun also led the team to continue to output high -level research results in basic scientific research.

In 2012, Xu Xun and his team first realized the sequence of solid tumor single cell genome in the world, and built a tree cloning evolution system of cancer cells. Cancer and development play an important role of cell heterogeneity and key genes. The result is published in the academic journal Cell. The "Genome Research" reviews the article "Five -Year Development and Future Outlook for Single Cell Tumor Sequencing and Future Outlook". This result is the milestone in the field of tumor sequence in the field of tumor sequences.

In April of this year, DNBLAB C4, based on the independent development of the single -cell micro -current control system, and the journal of Huayan than the Nature released the world's first non -human long animal all -cell map, and on this basis Wait for 126 viral virus databases. In May, using the self-developed time and space group Stereo-SEQ technology, Huada first draws four types of biological embryo development or organ of the time and space. For the first time, this series of studies analyzed the genes and cell changes in the development of life from time and space dimension, and opened a new field of life research. The results were published on the official website of CELL Publishing House in the form of time and space group.

In September, the first brain regeneration time and space map led by Huada was published in the form of back -to -back articles in the form of back -to -back articles on the international academic journal Science, which is also the world's first brain regeneration space -time map. Based on the Huada Time and Space Learning Stereo-SEQ technology, the research team systematically analyzes and compares the brain development and regeneration process. The process of damage to the neurons also found that the brain regeneration and development process have certain similarities, providing a support for cognitive brain structure and development process, and providing new directions for the regeneration medical research and treatment of the nervous system.

In addition, he also led the team to reveal the general rules of the mutation of the genome of the family nourishment and plant genome by multiple typical home -breeding and plant models. Among them, corn-related research results are published in "Nature-Genetics" in two cover articles, and the research results of rice and valley are published in "Nature-Biotechnology".

[Welcome to the 20th National Congress, Forge a new journey]

Xu Xun: It is precisely because of Yantian related policies that we have gathered hundreds of excellent scientific and technological workers returning from overseas to provide talent support for continuous scientific research results. In the future, I believe that there is sufficient space venue, the guarantee of talent development, and a virtuous circle of self -hematopoiesis and self -industry incubation. We can have a greater breakthrough in cutting -edge technology. The life and health industry must be promising in Yantian, Shenzhen.

Since 2021, I have been a member of the Shenzhen CPPCC. I have given full play to the use of my own advantages, timely understanding, mastering and reflecting the demands and difficulties in the science and technology community, and actively write proposals to provide decision -making for Shenzhen's construction of global influential technology and industrial innovation highlands. support. When the 20th National Congress of the Communist Party of China is coming, I will also do my job to make new contributions to the development of Yantian District, Shenzhen Development, and China's genetic science and technology development.

【Biography】

Xu Xun, born in 1984, Dean of Shenzhen Huada Life Sciences. At present, more than two hundred international top scientific journal research papers have been published in the fields of single -cell, gene sequencing technology, and genome research. The number of references in the past five years has reached more than 24,000 times. 47 patents authorized invention. Hosted or participated in 14 scientific and technological projects including the National 863 Sequential Development Project, the National Key R & D Plan, and the Industrial Collective Project of the Development and Reform Commission. He has won the first prize of "Ministry of Science and Technology Challenge Young Scientists", "Pengcheng Outstanding Talent Award", "Guangdong Provincial Science and Technology Award", and the second prize of "Ministry of Education Natural Science Award". In July 2020, he was selected as a national talent project, and awarded the honorary title of "outstanding contribution to young and middle -aged experts". In 2022, he was awarded the "Most Beautiful Science and Technology Workers" and Shenzhen "Most Beautiful Science and Technology Workers" honor in 2022.

Guangdong Science and Technology News reporter Zhang Wenxin

The picture of this article is provided by the respondent

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