"Mengwu" research appeal on the cover of "Science" 蝾螈 regeneration is expected to help the human brain regeneration

Text/Yangcheng Evening News reporter Lin Qingqing Correspondent Hao Li Zhang Lanxi Jin Ting

Photo/Interviewee provided

"Mengwu" 登 has recently appeared on the cover of the international top journal "Science" (as shown above), because the soft and cute appearance has this ability: some brain tissues are removed by surgery, and they can be reborn after two months. Restoration, regeneration neurons are similar to before loss; after the damage of the body regeneration, the skin, nerves, and muscles can also grow properly like the old as the old.

The results of the research were from Hangzhou Huada Life Sciences, Shenzhen Huada Life Sciences Research Institute, Guangdong People's Hospital, the School of Life Sciences of the University of China, Shenzhen Bay Laboratory, Whitehead Institute of Biomedical, Danish University of Copenhagen, etc. 17 units in China, the United States, and Denmark jointly cooperated together.

Fei Jifeng, a member of the team and a professor at the Medical Research Center of the Guangdong Provincial People's Hospital, said that the study revealed the important "switch" of launching the brain regeneration. Through further research, it is expected to solve the mystery of regeneration to repair the human brain, and provide effective clinical solutions for the treatment of brain degenerative diseases (such as Parkinson, Alzheimer's dementia, etc.) and other brain injury.

Damaged cells can "return to the old age"

"At present, after the brain is damaged, it still lacks effective treatment methods in clinical practice. How to find the method of damaging the brain, especially the regeneration of the nervous system?" Fei Jifeng said in an interview with the Yangcheng Evening News reporter: "蝾螈 Yes, yes, yes At present, the champion of the four -foot vertebrate regeneration, and its brain structure is very similar to mammals such as humans or mice. We can use 蝾螈 to perfectly repair the characteristics of the damaged brain and find the starting brain to start the brain. Regenerative repair 'seed' cells, and drawing a blueprint for the regeneration of the brain. "

How powerful is the regeneration ability? "We found that even if the brain was removed a large part, two months later, the brain injury area was reborn and recovered. Moreover, in this rebirth area, the type of lost cells was" just right ', and it came back. The neurons of regeneration are similar to the height before the loss. "Fei Jifeng said.

"The research team took two and a half years to build the time and space diagram of brain development and regeneration single -cell. We found the key 'seed cells' in the pupa -one type is different from the brain adult nerve nerve nerves Stem cells, but the sub -groups that are very similar to early stem cells in the early stages of development. "Fei Jifeng said," We also found that there is a process of reverse development after this 'seed cell' is damaged. That is to say, the regeneration mechanism of 蝾螈 is the restart of development, and the "return old child" of the brain nerve stem cells. "

Project final serving brain disease treatment

What is the significance of studying the regeneration mechanism of 蝾螈? Fei Jifeng said that the regeneration and repair ability of most human organs is very weak, and the gene encoding sequence of 蝾螈 is very similar to humans. After discovering the key "seed cells" and mechanisms of recycling after the brain injury, the research plan for the next step of the research team is to achieve brain regeneration in mammals including humans. "Among them, the activation of the brain 'seed cells' and the introduction of key factor, thereby opening the" switch "of the human brain regeneration." Fei Jifeng said that after the research plan is finally successfully implemented, it is expected to formulate new treatment methods to improve brain diseases to improve brain diseases Patient's clinical rehabilitation -that is, realize the regeneration of the human brain.

The team currently carries out the research work of the multi -organization and organ regeneration mechanism, which is expected to help improve the formulation of other human organ and organ regeneration strategies: "After the limb injury, the skin, bones, nerves, and muscles can grow again. The internal organs such as the heart and kidneys can also be regenerated and repaired, so the regeneration ability of the 蝾螈 is also expected to be applied to human clinical -related limbs and internal organs regeneration. "

Fei Jifeng (left) in Guangzhou Laboratory

"蝾螈 Dad" specializing in 爸 research for 20 years

"It is very cute, and someone raises it as a pet." Fei Jifeng, who has been talking with Mexico for more than 20 years, has been interested in showing reporters various pictures of 蝾螈, "My daughter -in -law nicknamed me It's '爸 Dad' ".

"The physical regeneration phenomenon of this species was first reported for the first time 150 years ago, and then for a long time as a model creature. But compared with mice and fruit flies, it is too niche!" As the research group of the research object, Mexico's blunt mouth does not exceed more than one hundred globally.

"From the beginning of contact, I have been deeply attracted by the magical ability of this cute little animal." Fei Jifeng said that his teacher from the Director and Professor of the Institute of Biology and Genetics of Max Planck in Germany Wieland Huttner During a doctorate degree, Elly Tanaka's research group with scientists and professors in the field of top international organizations and organs held a joint topic seminar every week.官 The powerful tissue and organ regeneration ability aroused his curiosity. Therefore, after completing the doctoral dissertation, Fei Jifeng decided to join the Tanaka research group, and the research direction was transferred from the use of mammalian brain development to exploring the brain regeneration mechanism by using amphibians. After returning to China, Fei Jifeng established a unique experimental platform in the world's leading in the world with Mexican blunt mouth as a model to study tissue organs.

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