"Mengwu" on the cover of "Science"!From the regeneration to the regeneration of the human brain, Guangdong experts found the "switch"

Text/Yangcheng Evening News reporter Lin Qingqing Correspondent Hao Li Zhang Lanxi Jin Ting

Photo/Interviewee Confer

If time can be retreated and the injuries can be reunited, the length of human life may be re -calculated. How to let time go back? While physicists explore the mystery of time and space, biologists are also diligent in different paths.

After the surgical removal of the brain tissue, it can still be reborn and recover after two months. The regenerative neurons are similar to the height before the loss? After the damaged limb regeneration, can the skin, nerves, and muscles grow properly like the old? The species with this powerful regeneration ability in nature is actually soft and cute! As a pet in some places, it may not know that they have become a niche model creature. They are studied by scientists from all over the world from different directions and paths. They hope to decode its regeneration ability and benefit humanity.

"Science" magazine on September 2nd

Recently, "Mengwu" was on the cover of the top international journal "Science". As a co -communication authors, Guangdong Provincial People's Hospital, united many domestic and foreign research institutions at home and abroad, published in this issue of "Science" entitled "Use the key stem cell subtype of time and space transcription group technology to analyze the brain regeneration" " Original papers, together with the European Research Group and the United States, have become one of the three papers of the cover theme "Back Published". Professor Fei Jifeng of the Medical Research Center of the hospital stated that the study revealed the important "switch" of launching the brain regeneration. Through further in -depth research, it is expected to solve the mystery of regenerating the human brain and provide effective clinical solutions for the treatment of brain degenerative diseases (such as Parkinson, Alzheimer's dementia, etc.) and other brain injury.

Can the cells "return to the old" after the cells are damaged? " Decoding "Mengwu" regeneration "switch"

"The brain is the most complicated and important organs in the human body. However, after being damaged, the brain still lacks effective treatment methods in clinical practice. How to find the method of damaging the brain, especially the regeneration of the nervous system?" Professor Fei Jifeng accepted the Yangcheng Evening News In an interview with the reporter, "目前 is currently known champion of the four -foot vertebrate regeneration. We use the characteristics of 蝾螈 to perfectly repair the damaged brain and find the 'seeds' cells that start the brain regeneration and repair, and and and and of. Draw a blueprint for the regeneration of the brain. "

"At present, there are many species with regeneration capabilities in nature, including vortex, 蝾螈, crab, starfish, gecko, and even sika deer (velvet antler). Their regeneration capabilities have different characteristics. A large amount of blood red blood cells help carry oxygen and nutrients. It is generally believed that the lower the position in biological evolution, the stronger the regeneration ability. "Fei Jifeng explained that as a four -foot vertebrate, the regeneration ability of the nervous system is very strong. And its brain structure is very similar to mammals such as humans or mice.

How powerful is the regeneration ability? The research team established a brain injury model for 蝾螈. "We found that even if the brain was removed a lot, the brain injury area was reborn and recovered two months later. In this rebirth area, the lost cell types were" back to "just right, and the regeneration was back, and the regeneration was regenerated. The neurons are similar to the height before the loss. "Fei Jifeng further explained to reporters that if the repairs are too fast, it will easily become a tumor; if the repair is too slow, it cannot effectively achieve the purpose of rapid regeneration. How to control different cell types to be reborn according to the "rhythm"? This just proves the magical and powerful regeneration ability.

The research team took two and a half years to compare the left and right hemispheres of the brain in the damage model before and after the injury, and identified the key nerve stem cell subtypes participating in the brain regeneration. "We have built the time and space diagram of the brain development and regeneration single -cell. We combine the regeneration process of a classic model creature with the latest technologies such as single -cell technology and spatial group technology. The key 'seed cells' -one type is different from the brain adult neuronal stem cells, but it is very similar to that of the early stem cell state. "Fei Jifeng said," In addition, we also discovered this 'seed cell' from embryo. Changes from early development to adulthood development. After it is damaged, there is a process of inverse development, which is very similar to the early stages of embryo development. Its regeneration process is similar to the development process. The regeneration mechanism is the restart of development, the "return old child" of the brain nerve stem cells. "

How many steps are there from regeneration to regeneration of human brain?

What is the significance of studying the regeneration mechanism of 蝾螈? Fei Jifeng said that most of the human organs were formed in the process of developing in the early days of embryo. With age, accidents or diseases, organ damage and failure can be caused. Most human organs have weak regeneration and repair capabilities. The gene encoding sequence of 序 is very similar to humans. After discovering the key "seed" cells and mechanisms of recycling after the brain injury, the research plan for the next step of the research team is to achieve brain regeneration in the body including humans. "Among them, the activation of the brain 'cell cells' and the introduction of key factor, thereby opening the" switch "of the human brain regeneration." Fei Jifeng said that the successful implementation of the final research plan will be expected to formulate new treatment methods for use for use for use for it for use for use for use for use for use for use for use for use for use for use for use for use for use for use for it. Improve the clinical rehabilitation of patients with brain diseases -that is, the regeneration of human brain regeneration. At the same time, the research work of the multi -organization and organ regeneration mechanism currently carried out by the team is also expected to learn from the formulation of other human organ and organ regeneration strategies. "After the limb injury, the skin, bones, nerves, and muscles can grow again. Its heart, kidney and other internal organs can also be renewed and repaired. In the field of internal organs. "

"Dad Dad" talks: From "Meng Pet" to Mode creatures

"It is very cute, and some places even raise it as pets." Fei Jifeng, who has been talking with Mexico for more than 20 years, has been interested in showing reporters various pictures of 蝾螈 蝾螈 “ "My daughter -in -law also joked that I was '蝾螈 蝾螈'."

"The physical regeneration phenomenon of this species was first reported for the first time 150 years ago, and then for a long time as a model creature. But compared with mice and fruit flies, it is too niche!" A niche model creature, using Mexico's blunt mouth as a research object group, does not exceed more than one hundred globally. Compared with mice commonly used in the medical field, there is a bottleneck of genetic tools and lack of resources, which seriously limits the in -depth analysis of the regeneration mechanism.

"From the beginning of contact, I was deeply attracted by the magical ability of this cute little animal." Fei Jifeng said that his teacher Professor Wieland Huttner, Director of the Institute of Biology and Genetics, Max Planck in Germany, was studying Dr. Wieland Huttner. During the degree, Professor Elly Tanaka, a scientist in the field of top international organization and organ regeneration, held a joint topic seminar once a week.官 The powerful tissue and organ regeneration ability aroused his curiosity. So after completing the doctoral dissertation, Fei Jifeng decided to join the Tanaka research group, and the research direction was transferred from the use of mammalian brain to explore the brain regeneration mechanism by using amphibians. From the perspective of brain development (first built) and regeneration (reconstruction), it is necessary to tap why mammals, including humans, cannot regenerate the damage brain. During the post -doctoral period, Fei Jifeng established a series of gene editing methods based on CRISPR/CAS9 technology for the first time in the puppet, achieving the genetic operation of the target gene and the genetic trace of the target cell type.

After returning to China, Fei Jifeng established a unique experimental platform in the world's leading in the world with Mexican blunt mouth as a model to study tissue organs. In recent years, it has cooperated with many research teams such as Professor Tanaka to analyze the Mexican blunt cheat genome and is one of the largest animal genomes currently sequensed by humans.

Source | Yangcheng Evening News · Yangcheng School

Responsible | Niu Zhijie

School Delivery | Zhao Dandan

- END -