Save Dunhuang murals into DNA!9.4 degrees Celsius, unchanged for 20,000 years

Text ｜ "China Science News" reporter Chen Bin

Zhao Hui

A few days ago, it was learned from Tianjin University that the school's synthetic biology team innovated DNA storage algorithm and stored ten selected Dunhuang murals into DNA. Through accelerated aging experimental verification, mural information could be preserved for thousands of years at 9.4 ° at 9.4 °, at 9.4 ° It can be stored for 20,000 years under C.

This algorithm supports DNA molecules to become one of the world's most reliable data storage media, which can keep the human cultural heritage information facing the crisis of aging damage for thousands of years.

Dunhuang mural stored in DNA. Picture of Tianjin University

From the note of the rope, the modern magnetic optoelectronic storage technology such as Cangjie to the tape, hard disk, etc., the development of human civilization is closely related to storage technology. With the advancement of science and technology, the data storage method continues to iterate and innovate.

Yuan Yingjin, an academician of the Chinese Academy of Sciences and a professor of Tianjin University, has been committed to the next generation of storage technology -DNA storage. "According to international data companies, the total global data will reach an amazing 175 ZB (1 ZB ≈ 1021 bytes) by 2025. The world is under construction, and the energy consumption of the data center is amazing. DNA storage is due to its The characteristics of high storage density and low energy consumption treatment are considered a great potential storage technology, which has become a new opportunity to deal with the challenge of data storage growth. "Yuan Yingjin introduced.

In August 2021, Yuanying's team obtained a major breakthrough in DNA storage. The team's coding design synthesized a length of 254886 base pairs and dedicated to data storage. In the artificial dye, it uses yeast reproduction to achieve stable data replication, and use nano -hole sequencing devices to achieve data quickly read and recover from errors.

DNA storage is efficient and low -consumption, but as a chain biological macromolecules, it will face risks such as DNA breakdown degradation when it is stored in vitro. It seriously affects the long -term reliability of information storage. It is a key scientific issue that needs to be solved. In this regard, Yuanying's team designed a sequence reconstruction algorithm based on the theory of Delblayingtu to solve the problem of DNA breaks. This algorithm combines the greedy path search and the circular redundant school code to achieve the efficient assembly of the broken DNA fragment from the beginning, which supports the long -term reliability of DNA storage in principle.

Combined with the sequence reconstruction algorithm (inner code) and the fountain code algorithm (outer code), the team design coded 6.8 MB Dunhuang murals, synthesizing 210,000 DNA fragments carrying picture information. For the long -term reliability of the data, the team prepared a DNA aqueous solution sample without any special protection, and accelerated the sample breaks and degradation for ten weeks at 70 ° C. More than 80%of the DNA fragments are processed. There have been broken errors. Relying on the design sequence reconstruction algorithm can still accurately assemble and decode more than 96.4%of fragments, and then solve the problem of a small amount of fragments through the fountain code. Perfect recovery.

According to theoretical calculation, this level of high temperature damage is equivalent to a natural preservation of a laboratory at 25 ° C or 9.4 ° C for 20,000 years.

It is reported that this is an important breakthrough in Tianjin University's synthetic biology team after the yeast internal information storage model based on artificial synthetic chromosomes has achieved breakthroughs.

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Edit | Li Yun

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