Major breakthrough!Let Dunhuang murals and other information be preserved for thousands of years

The reporter recently learned from Tianjin University that the school's synthetic biology team innovated DNA storage algorithm and stored ten selected Dunhuang murals into DNA. Through accelerated aging experimental verification, mural information can be preserved for thousands of years at the normal temperature of the laboratory, 9.4 ° at 9.4 °, It can be stored for 20,000 years under C. This algorithm supports DNA molecules to become one of the world's most reliable data storage media, which can keep the human cultural heritage information facing the crisis of aging damage for thousands of years.

From the rope notes, Cangjie, to the modern magnetic optoelectronics storage technology such as tapes and hard disks, the development of human civilization is closely related to storage technology. With the advancement of science and technology, the data storage method continues to iterate and innovate. Academician of the Chinese Academy of Sciences and Professor Yuanjin University of Tianjin University has been committed to studying the next generation of storage technology -DNA storage.

Dunhuang mural stored in DNA storage

"According to international data companies, the total global data will reach an amazing 175 ZB (1 ZB ≈ 10 (21 (21 of the 1 ZB ≈ 10) in the world by 2025. The world is under construction, and the energy consumption of the data center will be amazing. DNA storage is considered a new opportunity to deal with the growth of data storage due to its high storage density and low energy consumption processing, which is a new opportunity for data storage growth. "Academician Yuan Yingjin said.

In August 2021, Professor Yuan Yingjin's team obtained a major breakthrough in DNA storage. The work and subsequent research content has been published in "National Science Review" and "Science China-Life Sciences".

DNA storage technology concept map

DNA storage is efficient and low -consumption, but as a chain biological macromolecules, it will face risks such as DNA breakdown degradation when it is stored in vitro. It seriously affects the long -term reliability of information storage. It is a key scientific issue that needs to be solved. In this regard, Yuanying's team designed a sequence reconstruction algorithm based on the theory of Delblayingtu to solve the problem of DNA breaks. This algorithm combines the greedy path search and the circular redundant school code to achieve the efficient assembly of the broken DNA fragment from the beginning, which supports the long -term reliability of DNA storage in principle.

The sequence reconstruction algorithm designed based on the Dablaying Tu Tu theory efficiently solve the problem of DNA breaks and degradation

Combined with the sequence reconstruction algorithm (inner code) and the fountain code algorithm (outer code), the team design coded 6.8 MB Dunhuang murals, synthesizing 210,000 DNA fragments carrying picture information. For the long -term reliability of the data, the team prepared a DNA aqueous solution sample without any special protection, and accelerated the sample breaks and degradation for ten weeks at 70 ° C. More than 80%of the DNA fragments are processed. There have been broken errors. Relying on the design sequence reconstruction algorithm can still accurately assemble and decode more than 96.4%of fragments, and then solve the problem of a small amount of fragments through the fountain code. Perfect recovery. According to theoretical calculation, this level of high temperature damage is equivalent to a natural preservation of a laboratory at 25 ° C or 9.4 ° C for 20,000 years.

According to reports, this is an important breakthrough in Tianjin University's synthetic biology team after a breakthrough in in vivo -in vitro -based information storage model based on artificial synthetic chromosomes.

Source: Workers' Daily Client (Reporter Zhang Xi Correspondent Zhao Hui)

Edit: Zhang Jinmin Responsible: Zhu Wang School Review: Du Yingsing

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