What else can humans do in scientific research?| Rongge Caido

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Recently artificial intelligence Alphaflod

That is, Alpha Folding

There is a scene again,

It is the star AI company DeepMind

Another new achievement sweeping the world.

The research team announced that it has predicted

About 1 million species

More than 200 million protein spatial structure,

Covers all proteins that have been recorded in almost the scientific community.

What should I think of this,

It is worth talking to you.

Protein is the basis of life,

There is no life without protein.

Take people as an example,

Protein accounts for about 18%of human weight,

All important parts of the body

Both need to participate in protein.

From another perspective,

Adult weighing 70%is water,

More than half of the remaining parts are protein,

You can also see the importance of protein.

Looking back on the definition of protein,

It is dehydrated by amino acids by dehydration

The polypeptide chain

Formed by folding

Materials with a certain space structure.

That is,

Amino acid is a protein part,

We can ingest protein through food,

Digestive disassembly into amino acids,

The body can also create amino acids.

Then arrange them to assemble them according to our requirements.

But this is not enough, there must be a spatial structure,

It's like you have to hold your chest again

Or you can leave the factory after bending down and turning your head.

Formally go to work.

Different space structures in the same ingredients

It will lead to huge differences in macro -macro performance.

The most common examples are graphite and diamond.

Speaking of everyone is carbon,

But a very software as a lubricant,

A very best drill.

For organic macrons like protein,

The difference is even greater.

Energy, currency, adenosine in our body, adenosine,

That is, ATP is an example.

It is the energy that our cells can use directly,

And the protein that transforms energy

The shape looks like a water turbine blade,

Embedded on the cell membrane,

When there is a difference in ionic concentration on both sides of the cell membrane,

There will be an ion flowing, pushing the leaves to rotate,

Energy was transformed and passed out.

Although energy storage release is a chemical process,

But the key link in the conversion is a physical process,

Quite a bit like the energy storage water station we said before.

Apply a line commonly used lines for short videos,

If you don't see your own eyes,

I never dare to believe it.

So find out what the protein looks like

It is important for us to explore the mystery of life.

ATP synthase structure schematic diagram

A pile of amino acids are connected in different order,

Will

The influence of hydrophilic hydrophobicity and other factors

Fold into different spatial structures.

Although the study of protein folding mechanism

It's still junior now,

There are only some hypothesis.

But this does not hinder us

Start with determining the protein spatial structure,

Find the rules to discover internal connections.

However, traditional use of synchronous radiation accelerator

Method of the large device,

Although let us see the micro world.

But efficiency is really hard to say, spend money and take time.

And the results are scattered and scattered.

So change the track,

Like training Alpha Dogs, Go to Go,

Put a large amount of known data and laws

Keep feeding Alpha folding,

Let it keep learning and correction,

Approach the truth step by step.

Speaking of each protein

We were selected in the evolution of hundreds of millions of years,

They all have their unique working ability.

Although the accuracy of Alpha folding is not 100%,

Even 35%of the high degree of accurate is comparable to the results of the experimental measurement.

But compared to experimental measurement

From cost to speed, there are more than a few orders of magnitude.

European Institute of Biological Information said,

"Alpha Folding Protein Structure Database"

Since one year of launch,

More than 500,000 researchers around the world have visited.

As more and more people use, more and more feedback, more and more feedback,

There is a positive confirmation that there is error correction correction,

As the most desired high -quality data for machine learning

It will be continuously mined.

This is a virtuous follow -up,

The predictive accuracy rate will also be inevitable.

And Brother Rong believes,

The arrival of this day will only be faster than you think.

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