Huang Dongsheng team of Hangzhou Medical College: Response hydrogel synthesis based on trigger clicks and applications in liver cancer treatment

Recently, the team of Professor Huang Dongsheng of Hangzhou Medical College published a review of the "Responsive Hydrogel Based Click Reaction for Liver Cancer" in "Advanced Materials" (IF = 32.086). Zhu Jiaqi, a graduate student of Professor Huang Dongsheng, is the first author of the dissertation, Professor Huang Dongsheng and Professor Yang Tian, ​​a special professor of Hangzhou Medical College.

Water gel is a three -dimensional mesh structure containing a large amount of aquatic molecules. Different sizes of pores in its network allow other small molecules to penetrate and spread in them, and it has good biocompatibility and biodegradability. Make it a good pharmaceutical platform. In the construction of the nanometer gel carrier platform, it was found that a large number of research results on the construction of response nano -composite hydraulic pharmaceutical systems were published, including PH, temperature, light, enzyme, ultrasound and other irritating response release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release release released Essence The author made a comprehensive summary of the progress of the nano -composite hydraulic pharmaceutical system based on the team's previous work foundation and in -depth research in related fields (Figure 1).

The synthesis and stimulus response of hydrogel regulation and control of drugs

Primary liver cancer is one of the most incidence of vitality in the world. Nearly half of the world's liver cancer patients are in China. The diagnosis of early liver cancer is difficult. Most patients with liver cancer are the first diagnosis of liver cancer. The treatment methods such as surgical resection and liver transplantation have been missed. The prognosis is quite poor. The current treatment of systems such as targeted and immune brings dawn to patients with advanced liver cancer, but the effect is limited, the side effects are large, and the drug resistance is high. Therefore, how to develop more and more effective transmission carriers targeted by liver cancer or tumor has attracted the attention of many scientific researchers. Water gel is a soft three -dimensional network material containing a large amount of hydrophilic monomer. By adding nitrics and other groups to the network structure of the cross -linking nano -compound hydrogel, the efficiency of drug release efficiency in the body is improved by clicking the reaction, thereby improving the survival rate of patients with liver cancer and extending the survival time of patients with liver cancer. The application of nano composite hydrogel feeding system can not only enrich the drug concentration of tumor parts for a long time, but also effectively prevent the distant metastasis of residual tumor cells. At present, a large number of studies have been studied in the construction of response nano -composite hydrogel drug delivery systems, but few comprehensive articles summarize these discoveries. This article summarizes the synthesis method and related applications of nano -composite response hydrogels that work on external or internal physiological stimuli. Under different physical or chemical stimuli, the structural unit of the drug can be used for response drug delivery in different states.

In the exploration of the selection of nanometer gel carrier platforms, Professor Huang Dongsheng's team fully learned about the latest research progress and found that a considerable number of research on the construction of response nano -composite hydraulic pharmaceutical system has been published. These studies have passed PH through pH , Temperature, light, enzyme, ultrasound and other methods can stimulate the releasing drugs for response hydrogel (Figure 2). In this article, the team systematically summarizes the synthesis of various composite hydrogel platforms and its application classification in liver cancer diagnosis and treatment, which is conducive to the comprehensive understanding and forward -looking prospects of peer scholars. The cutting -edge excavation exploration has important guiding significance.

Stimulating response to regulating nano composite hydrogel formation and application

Full text link:

https://onlineelibrary.wiley.com/doi/abs/10.1002/adma.202201651

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