Hangzhou Huada Life Sciences Research Institute released the first brain regeneration time and space map

On September 2nd, the unveiling ceremony of the Hangzhou Huada Life Sciences Research Institute was held in Hangzhou. The first phase of research results was also released at the scene -the world's first brain regeneration space -time map. This research will provide the cognitive brain structure and development process. Help provides new directions for the research and treatment of regeneration and treatment of the nervous system.

This study was led by the Hangzhou Huada Life Sciences Research Institute, and jointly cooperated in cooperation with 17 units from China, the United States, and Denmark. On the same day, this research results were also published in the form of back -to -back cover articles in the top international academic journal "Science".

Based on the Huada Time and Space Learning Stereo-SEQ technology, the research team systematically analyzes and compares the brain development and regeneration process. The process of damaging neurons also found that the brain regeneration and development process have certain similarities.

The Mexican blunt mouth used in this study is a kind of cricket, which is cultivated for laboratory. Mexico's blunt mouth can not only regenerate the limbs, tails, eyes, skin, and liver, but also can even regenerate the brain. Therefore, scientists are used as important model creatures to study regeneration related problems.

"In addition to strong regeneration capabilities, it has higher similarities from evolution than other hard bone fish. At the same time, its gene encoding sequence is extremely similar to humans. Study 蝾螈The start -up mechanism of brain regeneration discovers the key genes will provide important guidance for the restoration of human nervous system damage or degenerate diseases. "Gu Ying, the author of the common communication of the paper and Ph.D. in the Hangzhou Huada Life Science Research Institute.

In this study, the research team first built the time and space map of brain development that covered 6 important periods of development, showing the molecular characteristics of various neurons and dynamic changes in spatial distribution. It turns out the stem cell subtype with spatial regional characteristics.

According to reports, in order to study the regeneration process after brain injury, the research team underwent mechanical damage surgery of the cortex area of ​​the brain, and 7 time points for regeneration (day after the second, 5th, and 10th day of day Analysis of the brain samples of the 15th, 20th, 30th and 60th days).

By comparing the neuron formation process of brain development and regeneration process, scientific researchers have found that this process is highly similar in the process of regeneration and development, suggesting that brain damage may induce the damage to restart the development procedures.

"The construction of brain development and regeneration space -time cell map is of great significance for our understanding of the important life process of the brain regeneration, amphibious animal brain structure, and the evolution of the brain structure. It is necessary to find effective clinical treatment methods for us to promote humans. The self -repair and regeneration of organizational organs provides a new direction, and also provides valuable data resources for species evolution research. "Xu Xun, the common communication author of the paper and the dean of the Chinese Academy of Life Sciences, said.

At the press conference, under the witness of the leaders of Hangzhou and West Lake District Government departments, Hangzhou Huada Life Sciences Research Institute, the Chinese Academy of Sciences Institute-Hangzhou Huada Research Institute Joint Laboratory, Hangzhou Huada Research Institute-Hangzhou Academy of Agricultural Sciences joint joint The laboratory was officially unveiled.

Hangzhou Huada Research Institute unveiled

It is reported that the Hangzhou Huada Life Research Institute will focus on the forefront and key issues of the basic research field of life science, and build the "five centers and three platforms", that is, the five major research centers of group science technology, synthetic biology, aging and regeneration, cell intervention, and brain science , Single cell space -time group, high -throughput sequencing, and high -throughput gene control.

Source ｜ China News Network. The copyright belongs to the original author.

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