"Tiaopong Project" will open up the secret pig facilities in the world in Lizhou, Hebei

What kind of animal can pigs make a common animal that can make for life science research? In the National Agricultural Science and Technology Park in Baoding, Hebei, there is a "Tiantong Project" specializing in scientific research and results incubation around pigs, that is, the model animal table type and genetic major national science and technology infrastructure project. In the golden autumn season, the project's infrastructure project has entered the completion acceptance process. It is expected to be completed in mid -September, and it will be put into use according to the installation of the equipment.

"Model animal phenotype and genetic research facility" is a major scientific and technological infrastructure of my country's "Twelfth Five -Year Plan". The main purpose is to carry out precise determination and genetic research of large -scale animal surface patterns to analyze the laws of life, and for disease treatment, medicine, medicine, medicine, medicine, medicine R & D, animal breeding and other fields provide major platform support. The long -term facilities of spiritual facilities in the Kunming Institute of the Chinese Academy of Sciences; the construction of pig facilities for the establishment of the "Tiaopong Project" by the Chinese Agricultural University. As the largest scientific facility in the world's largest animal -based animal, after the project is completed, it will establish my country's leading position in the field of large -scale models and genetic research in the world.

Why use pigs as moderate animals? What can "Tiaopong Engineering" do? How to ensure the best efficiency of animals such as pigs? The reporter recently interviewed Zhang Shuchuan, the head of the "Tiandong Engineering" project and the director of the Estate Construction Office of the Modeling Facilities of the Chinese Agricultural University.

Why use pigs as moderate animals?

The model animal refers to the specific animal species selected by the researchers to carry out scientific research and reveal some kind of life phenomenon, which is mainly used in the fields of life science, human medicine and health.

In the past, mice were often used as experimental objects in the field of life medical research. Its low cost, rapid reproduction, and easy breeding. Why did the "Tiandong Engineering" project selected a pig? "With the development of science, scientific researchers slowly discovered that in some diseases, drugs, etc., due to the large differences between mice and people, many research results cannot be applicable, and even new drugs developed will have strong side effects. . "Zhang Shuchuan explained that from many aspects such as organizational organs, physiological regulation, behavior patterns and genetic regulation mechanisms, pigs are very similar to humans, including weight, heart size, heartbeat, and people. Imported cardiovascular disease, metabolic diseases and organ transplantation research.

"Pig domestication has a long history, rich in genetic resources, convenient breeding, short breeding cycle, suitable for large -scale production, and there is no ethical problem. It is currently a more suitable model animal." Zhang Shuchuan said that pigs as large -scale models are research on human life activities. The important reference and living samples of the rules are a new way to break through the bottleneck of animal research in the existing model.

What can "Tiaopong Engineering" do?

"Compared to the little white rats, 'Master Brother' and" Brother Second Brother 'and others are closer. At present, the demand for experiments with monkeys and small pigs is also increasing. In our facilities, their purpose is complementary. " According to Zhang Shuchuan, monkeys are mostly used as a model animal for research on neuroma and infectious diseases; and pigs are used as model animals and are mostly used in research on cardiovascular disease and metabolic diseases.

According to reports, the project will support pigs as model animals in the study of human disease models, organ transplantation, and drug evaluation. At present, scientific researchers have obtained human disease model pigs such as atherosclerosis, polycystic kidney, congenital myocardial hypertrophy, etc., and developed a solution to solving genome selection of low -depth sequencing genetic typical division of genomes. Basic research, analysis of disease mechanisms, creation of heterogeneous organ, innovation of germplasm resource innovation.

In addition, after the completion of Pig Watch and genetic research facilities in Lizhou, it will also provide a scientific research foundation for high -quality and disease -resistant commercial pigs in terms of molecular breeding.

How does "Tiaopong" play the best efficiency?

The pigs raised by the "Peng Pong Engineering" are not ordinary pigs. It is understood that the experimental pig "Agricultural University 4 Series" selected by the "Tiandong Project" is a veritable "mixed race". One of their parents comes from China and the other party comes from Europe. After careful cultivation, the weight is only 50 kg. about.

These experimental pigs are divided into ordinary and SPFs (no specific pathogen) experimental pigs based on the degree of control of microorganisms and parasites. "In terms of biomedical research, vaccine manufacturing, heterogeneous organ transplantation, SPF experimental pigs need to be used." Zhang Shuchuan introduced that raising such pigs needs to be raised in barrier facilities, requiring isolation from the outside world, and with ordinary experimental pig air conditioners On the basis of the breeding environment, the breeding environment of the SPF experimental pig is equipped with a fresh air system. The air can enter the barrier facilities after being purified by three levels of filtration. Foreign objects should be strictly sterilized and sterilized to ensure clean environmental conditions. In addition, the project also set up a pig's "three hospitals" to purchase the most cutting -edge and high -end medical equipment. The test that people go to the hospital can do pigs here.

"Experimental pigs have strict breeding standards, and different nutrition formulas in different stages of development to ensure that they meet animal protein and energy needs, and ensure regular and quantitative feeding every day to achieve standardized cultivation of experiments." Zhang Shuchuan told reporters that doing so The purpose is to eliminate individual differences, try to ensure that the physiological state of each pig is consistent, and ensure the standardization of each pig type and genetic.

Source: Beijing Daily Client

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