Cheng Chengzheng published the cover thesis of the first chromosome genome in MOL PLANT

今年8月国际植物学顶级期刊《Molecular Plant》以封面文章刊登了题为“Allele- aware chromosome- level genome assembly of Artemisia annua reveals the correlation between ADS expansion and artemisinin yield（黄花蒿染色体级分型基因组揭示ADS Research papers (www.cell.com/molecular-plant/current) in the research papers of genetic expansion and artemisinin.

Guo Shuai, a doctoral student of Chengdu University of Traditional Chinese Medicine, is the first author of the paper. Professor Pei Jin, Associate Professor Gao Jihai and Chen Shiyu, etc., participated in this work as a co -author. The school's chief professor Chen Shilin was the author's communication author. The work was jointly completed by the Institute of Traditional Chinese Medicine of the Chinese Academy of Traditional Chinese Medicine, the Tianjin University of Traditional Chinese Medicine, the Artemisin Femain Research Center of the Chinese Academy of Traditional Chinese Medicine, and the Chengdu University of Traditional Chinese Medicine. author.

According to the relevant person in charge of Chengdu University of Traditional Chinese Medicine, the journal was published in the same period entitled "50th Anniversary of Artemisinin: From The Discovery to Allele-Aware Genome Assembly of Artemisia Annua (50th Anniversary of Memorial Research from Artemisinin: From discovery from artemisin to chromatin. Review article of genome assembly).

Artemisinin is the first -line drug of the World Health Organization for the treatment of malaria. Since its birth in 1972, it has saved hundreds of millions of human life. Researchers use a variety of sequencing technologies such as Pacbio HIFI, Bionano Optical Map, HI-C and other sequencing technologies to effectively bridge the scale differences between overlapping groups and chromosomes. The analysis of the mechanism of regulation and the molecular auxiliary breeding lays the foundation.

It is understood that the genome obtained by the study is the first high -quality genome of chromosomal levels of Aemisha chromosomes. Through the high -quality genome of Huanghua Artemisia annua, researchers have found that the number of key -limited enzymes auroenherase encoded gene ADS is highly related to the content of artemisinin content. Effective.

"This is of great significance to ensure the supply of the incidence of malaria at least 90%compared with 2015 by the WHO's raw material supply that guarantees the supply of high -quality and cheap global and cheap. At the same time, the high -quality genome of Artemisia annua adds a strong stroke to the "Thousands of Materia Medica Projects".

(Edit/Huo Wenwei)

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