Huada Group: Cracking the life passwords of multiple results "global start"

Text/Forest Garden Picture/Huada Group Pictures

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On August 18, Shenzhen ushered in the third anniversary of the construction of the first demonstration zone; on August 26, the Shenzhen Special Economic Zone ushered in the 42nd anniversary of the establishment; September 6 is a good day for the first anniversary of the release of the Qianhai Plan. In order to further tell the story of the Shenzhen Special Economic Zone, show the spirit of the spirit of Shenzhen's reform and opening up and the surging driving force for the construction of the "Shuang District" of Shenzhen, the Yangcheng Evening News launched the "Science and Technology Pioneer Brand Power -Entering Shenzhen First -class Enterprise" series reports Essence

Recently, the 2022 Natural Index annual list was officially released. Huada Group ranked first in the Asia -Pacific region in the ranking of life science industry institutions, the eighth in the world. head.

In the field of life sciences, Huada Group is a recognized industry leader, continuously exploring the mystery of life, and promoting the problems of solving various fields of life sciences.

On May 5th, the Time and Space League League (STOC) led by the Shenzhen Huada Life Sciences Research Institute and other institutions of the Huada Group announced its establishment. At present, more than 100 top scientists from 20 countries have joined the alliance to jointly promote the technical advantages of time and space groups in the four directions of organs, diseases, development and evolution, and promote the evolution of species, embryonic development, and disease mechanism. Research. The first phase of the alliance achieved the first batch of life and space map of life and space in the world. Recently, it was released on the official website of Cell Press in a special form.

In March of this year, researchers from many institutions such as the Chinese Academy of Sciences and the Chinese Academy of Sciences and other institutions induced the human all -around stem cells similar to the development of fertilized eggs for 3 days. Human cells are another disruptive breakthrough in the field of regeneration medicine after scientists successfully induced human multi -energy stem cells. In April of this year, the first non -human long animal (macaque) systemic organ cell map led by Shenzhen Huada Life Sciences and co -participating in the multinational research team was released in the international academic journal "Nature".

Behind the study gene is to find more secrets of nature. Recently, Huada Research Institute also used single -cell sequencing technology with domestic and foreign cooperative units to build four different types of brain cell maps of Ant, revealing the infantization phenomenon of brain and different social grade behaviors that the ants appeared with the division of social labor. The neurological foundation of the pattern difference shows the plastic changes in the brain during the maturity of the queen queen, and finds key cell groups that regulate their genitals and life. In addition, the Chinese Academy of Sciences also rebuilt the origin and evolution of penguins through multi -disciplinary joint methods, and used this as a case to reveal the role of environmental changes, climate and geological incidents in biological evolution. The molecular foundation explains how penguins adapt to the marine ecological environment.

"Pioneer" bravely break through the "uninhabited area"

After more than 20 years of development, Huada Group has taken its own way in the international and domestic biotechnology fields. In the "uninhabited area" of genetic technology, what kind of journey of the company has gone through, what kind of concept of talent training adhering to, and what is the vision of future development? The reporter interviewed Zhu Yanmei, executive director and executive vice president of Huada Group.

Talking about the "unmanned area": ​​the exploration and effort of "pioneer"

In Zhu Yanmei's view, the field of deep cultivation and development of Huada was originally a "uninhabited area". And the bravery of "uninhabited", Huada made many efforts.

"In the field of life science and genetic research, there are still many issues that have not been understood. As a 'pioneer', Huada needs to figure out scientific issues first, which is very different from companies in other fields." Zhu Yanmei said In this "uninhabited area", at the beginning, Huada's research can only rely on purchasing imported tools and instruments. It is understood that the gene sequencers used by the early Ambassador to import were imported from overseas, but later suffered various restrictions on overseas manufacturers, including high equipment maintenance costs, timely repairing, and price increases for supporting reagents. After being hit by real factors, in 2013, Huada completed the acquisition of the US company Complete Genomics, and conducted technical digestion, absorption and re -innovation, and developed gene sequencing instruments with completely independent intellectual property rights, breaking foreign countries, breaking foreign countries abroad The situation of technical monopoly. The control of the tool provides a strong underlying support for the breakthrough of technology and scientific research.

Furthermore, as a freshman, talents lack. At the same time, Huada shoulder the heavy responsibility of cultivating talents. "So we now have not only research institutes, our own instrument platforms, but also jointly cultivate talents with other universities and research institutions." Zhu Yanmei said.

"Unmanned areas" may even lack related industry standards. According to Zhu Yanmei, as a pioneer, Huada also participated in the formulation of industry standards in his development process. For example, in 2014, in order to regulate the industry, the State Food and Drug Administration, the State Health and Family Planning Commission jointly issued a notice to request that before the relevant access standards and management specifications were issued, no medical institution shall conduct a clinical application of gene sequencing. If it is carried out, stop immediately. "As a leader in the industry, Huada must first play an example." On the one hand, Huada suspended the relevant business, and on the other hand, Zhu Yanmei followed Wang Jianbin, chairman of Huada Group, to Beijing to communicate with the relevant management departments to let everyone let everyone let everyone go to everyone Understand this technology and its important significance faster and more clearly. Half a year later, the clinical application of non -invasive prenatal genetic testing finally obtained a "legal identity". Talk about talents: Create a "big tree" model

The growth of the enterprise is inseparable from talents. In 2012, when Zhu Yanmei joined Huada, there were more than 2,000 people in Huada.

Based on Wang Jian's thinking about the selection of talents, Zhu Yanmei has created the "big tree" model of Huada's talent "big tree" model, including A (abilities), T (personality characteristics), g (Goal-Driven, target driver), C (Change, self-change). She believes that the branches and leaves of the tree are capacity (A), the fruit is the goal (G), the root of the tree is the personality characteristics (T), the trunk is self -change and breakthrough (C). This model is a set of key capabilities and qualities required by Lord Hua, and it is also the standard for Zhu Yanmei and Huada to currently measure and choose "talents".

If the talent is metaphorized to the "big tree", the organization is "forest", and the ecological forest needs the four major elements of sunlight, water, air, and soil. Zhu Yanmei concluded the four "T" required for talents like "forests", namely Target, Transparence, TOLARANCE, Trust, and Trust. With these four "T" organizations, she must be the "forest" of talents. She is also creating such an ecological environment for the development of Huada's talents.

It is based on such talent selection standards and the ecological environment of the enterprise that Huada has gathered a group of people with ideal, scientific exploration and transcendence of material desire. The pioneering spirit of not fear of difficulties. Such people are not afraid of hardships and bravely in the "unmanned area" of life sciences.

Talking about vision: "genetic technology benefits humans"

The premise of cognitive life is the cognitive gene. Cracking the password of genes will bring extremely beautiful prospects and futures to improving human health, prevention of diseases, and extending life. Compared with other types of enterprises, Huada Group is more concerned about the field of people's livelihood and health.

Zhu Yanmei has always advocated "social enterprises". She believes that "social enterprises" are the ultimate ownership of all enterprises compared to companies with traditions for profit. Social enterprises are the primary goal of solving social problems and promoting social progress. Over the years, Hua has always adhered to the mission and original intention of "genetic technology to benefit humanity", and continued to benefit people's livelihood in the aspects of fighting the new crown epidemic and preventing and controlling Tang's syndrome, hereditary deafness, and cervical cancer.

Anti -hitting the new crown epidemic allows Huada's mission to be reflected. At the beginning of the epidemic in the country, Wang Jian, chairman of Huada Group, led the team to choose to rebel in Wuhan. With local support, the first "Fire Eye" laboratory was completed to carry out emergency detection of new crown viruses. From the first day of the first day, it can only detect more than 100 single tubes in the sample to realize the daily nucleic acid detection capacity of tens of thousands of single tubes. Prevention and control provides strong scientific and technological support. Subsequently, the "Fire Eye" laboratory moved to overseas as a Chinese business card for science and technology resistance, making important contributions to the improvement of the detection of detection in many countries and regions, and more accurately carrying out the epidemic prevention and control. This includes two "fire -eye" laboratory for Serbia to help Serbia's epidemic prevention and control. In February 2021, Serbian President Wugci gave China to the Chinese Anti -Epidemic Expert Group and Huada Group. Thanks to their contribution in Serbia's anti -epidemic work.

In the field of birth defects and tumor prevention and control, as of the end of 2021, Huada Gen has provided more than 10.42 million prenatal genetic testing. As the first province to comprehensively adopt non -invasive prenatal genetic testing technology for free prenatal screening, it may become the first province without Tang's syndrome. Huada also provided testing services for the screening of more than 4.94 million new students and adults, and found thousands of congenital deafness and late deafness, providing these deaf children and late deafness. Opportunities for early discovery and early treatment. Huada has provided HPV testing for more than 6.2 million women in more than 6.2 million, and it is simple and safe. Through timely clinical diagnosis or intervention treatment, the occurrence of cervical cancer is effectively prevented.

According to Zhu Yanmei, Hua Da's mission vision is "genetic technology benefit humanity". The first step is to help achieve "innate and disabled, acquired and less ill", prevent and control birth defects, infect infections, tumors, etc., help improve people's livelihood health The level, then gradually expand the application scenarios of genetic technology to further improve people's quality of life. Talking about the future development of the company, Zhu Yanmei believes that it is "eliminating several diseases." For example, there is no "Tang" yearning for the world. According to Zhu Yanmei, as a screening method, the detection rate of traditional Tang sieve technology is 60%-85%, and the false positive rate is high. According to the test results, it is also required to confirm the diagnosis of high-risk pregnant women. The cavity puncture is invasive and has a certain risk of abortion and teratogenic risk; while non -invasive prenatal genetic testing technology only needs to extract 5 ml of venous blood of pregnant women, it can detect the fetus suffering from the Tang family syndrome in the early pregnancy. The detection rate is as high as 99%of the risk of chromosomal abnormal diseases. Digital readings

As of April 2022, Washinga has published 4086 papers, of which 451 articles were published in international top academic journals such as "Nature", "Science", "Cell", and "New England Medical Magazine".

As of May 2022, Huada has applied for a total of 4,575 patents at home and abroad, and the countries that patent applications applications include 53 countries and regions including China, Europe, the United States, and Japan.

As of June 2022, Huada's innovative education model and concept have trained 226 students. There are more than 800 SCI articles that they have led and participated in the publication. More than 160 copyrights.

As of the end of 2021, Huada has provided more than 10.42 million prenatal detection.

Huadu provided hereditary deafness genes for more than 4.94 million new students and adults, and found thousands of congenital deafness and late deafness.

In China, it also provides HPV testing for more than 6.2 million women, and it is simple and safe. Nearly 100 "Fire Eye" laboratory in Huada "Fire Eye" laboratory overseas, distributed in more than 30 countries and regions around the world.

Source | Yangcheng Evening News · Yangcheng School

Editor -in -law | Li Cheng

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