Qinghai University Geli team achieved a leading internationally leading achievement -Tibetan mastiff's superpopular adaptation password was deciphered

Qinghai News Network · Damei Qinghai Client News Tibetan mastiff's super high -plateau adaptation mechanism and genetic laws are a difficult password for the plateau medical community. On August 2nd, experts from the Provincial Department of Science and Technology organized the Chinese Academy of Sciences, the Chinese People's Liberation Army Air Force Military Medical University and other units identified that they believed that the "Tibetan Mastiff and other plateau dogs such as Tibetan Mastiffs and the Plateau Animal Mechanism" project completed by Qinghai University's Geli Team The successful completion of the research tasks has extremely high breakthroughs and cutting -edge results to reach the international leading level. At this point, the Tibetan mastiff's superpopular adaptation password has been deciphered.

According to Professor Ge Rili, the team leader of the research group, Tibetan mastiff is one of the oldest and rare breeds in the world. In order to adapt to the extreme environment of the Qinghai -Tibet Plateau, it has effectively improved it in a relatively short period of time. Its "effective improvement" has an important enlightenment significance to clarify how humans adapt to the plateau, so it has become the focus of the entire plateau medical community. Due to other reasons for the difficulty of research, the above problems have been suspended for a long time. After the rigorous experimental design of this topic, through the analysis of the system development tree, the genetic evolution of the Mongolian mastiff, the Tibetan mastiff and the gray wolf was first clarified; through the contraction and expansion of the gene family, and the selection of genetic analysis, the Tibetan mastiff and the Gray Wolf adapted to the plateau for the first time to adapt to the plateau to the plateau. The molecular mechanism of long -term hypoxia, strong ultraviolet radiation, and cold extreme environment; through biological information analysis, the first time the Tibetan mastiff and the plateau gray wolf have the altitude tolerance adaptation of the positive genetic HBB (G13S and L14M and L14M ), And for the first time, the specific mechanism of this mutation was introduced; through further functional research, the mutation of a certain gene and genetic mutation for the first time can help improve the blood oxygen affinity of hemoglobin. Tibetan mastiffs and gray wolf adaptive advantages are given in high altitude areas.

Associate Professor Cai Chunmei, a core member of the research group, said that in -depth research on the evolutionary genetic laws and plateau adaptation mechanisms of high -altitude dogs such as Tibetan mastiffs and other high -altitude can provide universal insights for the adaptability of high altitude vertebrates, and for the prediction, diagnosis and treatment of plateau diseases, diagnosis and treatment Lay a good foundation with drug development.

Source: Qinghai Daily Author: Chen Yan

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