"German Applied Chemistry" reports new progress in the research of asymmetric catalytic transformation of Huawi Alexyne

Recently, Professor Chen Yifeng of the School of Chemistry and Molecular Engineering and Ferrich and Ferrich Nobel Prize Scientists in our university has achieved new research progress in the field of asymmetric catalytic transformation of olefins. The related research results are published in "German Applied Chemistry" in "German Applied Chemistry" in "Nickel-CatalyzedenaSelectictive Reductive Alkyl-CARBAMOYLATION OF InternaL Alkenes".

In recent years, the transition metal catalytic annemids internal asymmetric dual -agent -oriented regimental reactions have gradually become one of the most important ways to build a hand ring skeleton. Among them, nickel catalytic annemine reducing dual-official energy reaction can not only avoid the use of organic metal reagents, but also successfully introduce the C (SP3) coupling group in the catalytic system that is prone to occur in the catalytic catalytic system. At the end of the olefin, it has attracted much attention. At present, most studies are mainly concentrated in the endonne of the parent reagent. In comparison, the reaction of two consecutive hand -centered strategies through nickel catalytic endoilenes is still huge challenges. The possible reason is that the low -reactivity of the endoe and the low affinity of the endoe and the nickel catalyst further hindered the ring -in -line steps of the reaction, and the nature that is easy to cracked in the middle of the alkyl nickel after the ring combined increases Difficulty in selecting selective regulation.

The reflection of the transition metal catalytic amine metharocycles of the amine methalogenic reagent is one of the important methods of synthesis of handicide synthesis. In recent years, this method has received widespread attention from chemists. Professor Chen Yifeng's research group based on the asymmetric dual-aggregate reactions of the transitional metal catalysis to build a multi-hand-centered research interest. Through the further optimization of the hand 8-pyrodolinemidoline of the research group as the core skeleton ligand, it was further optimized. The nickel-catalytic endohydramine-alkyl-alkylated reaction is achieved, which provides a new, gentle and efficient method for the convenient synthesis of γ-lactide containing continuous hand. In addition, the research team also calculated DFT theory with the K. N. Houk project combination of the University of California Los Angeles (UCLA) in the K. N. Houk project combination of the Quinim ligand in the selected decision step. Theoretical calculation provides theoretical guidance for the reaction mechanism of nickel catalytic restoration of coupling chemistry and the further design and development of the Quinim handicap.

Wu Xianqing, a postdoctoral School of Chemistry and Molecular Engineering, and ANeta Turlik, a postdoctoral University of the University of California Los Angeles (UCLA), is the first author of UCLA. Professor K. N. Houk of UCLA and Professor Chen Yifeng of East China University of Technology are the joint communication authors of the work. The research work has been strongly supported and carefully guided by Professor Qu Jingping. The research work has received the Ministry of Materials Biology and Dynamic Chemistry Education Ministry of Science and Technology, Ferrich Knobel Award Scientist Joint Research Center, the National Natural Science Foundation of China, Shanghai "Qi Xing" plan, Shanghai Natural Science Foundation Project funds such as the fund scientific research business fee and the support of the Chinese post -doctoral science fund.

Original link: https://onlinelibrary.wiley.com/doi/10.1002/anie.202207536

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