Chinese silkworm research has achieved new progress of family silk glands single cell transcription group map paintings

The picture shows the main cell type of the family silk glands and its space -time distribution. Figures of the National Key Laboratory of Family Silkworm genome

China News Service, Chongqing, June 15th (Reporter Zhong Yan) Reporter learned from the National Key Laboratory of the Family Silkworm genome (Southwest University) on the 15th that there have been new progress in the study of house silkworms in my country. The laboratory Professor Xu Hanfu's research group recently published related theme research papers in Nature Communications of Nature Communications in the world -renowned journal Nature Communications, revealing the whole cell heterogeneity and gene transcriptional map of the family's silk glands with single -cell resolution.

This is the laboratory team following the 2003 decoding home silkworm whole genome DNA genetic password, and the first time the single -cell dimension is expressed to perform ultra -high resolution analysis of the dynamic dynamics of home -produced silk organs and their genes. Cell level leap.

According to reports, silk protein is a natural renewable protein resource given by nature to human beings. It has excellent mechanical properties, biocompatibility, and biodegradable characteristics. It has huge value for development and utilization.

The picture shows the spatial and space distribution and expression of the type of silk protein gene in each cell type. Figures of the National Key Laboratory of Family Silkworm genome

"The silk protein synthesis capacity of the silkworm is super strong. It is the only silk producing animal that has been completely domesticated by humans and formed an important industry." Xu Hanfu said that over 100 years, the molecular foundation of high -efficiency silk production of silkworms and the formation of silk traits has been proven. It is a key theoretical issue in the field of silkworm industry to make breakthroughs.

The study lasted two years, and the research team successively overcome technical difficulties such as a large number of silk gland samples of the silkworm gland samples and the solidarity of gland cells. A total of nearly 20,000 individuals who have anatomy embryo, ant silkworms, and one -year -old silkworms.

Studies have found that there are 10 major cell groups in the silk gland, which perform functions such as silk protein synthesis, synthesis of silk gum, liquid fibrosis, cell reconstruction, silk protein metabolism, and several metabolism.

It is worth noting that the silk protein gene is not only expressed in aging, but also has varying degrees of expression during the sleeping period. The gene expression in the rose gland cells is very active. Some signal transitional pathways such as molting hormone signals are involved, and they play an important role in regulating the development of rosin gonades and synthesis of silk protein.

"We usually have the most contact with people, such as silk quilts, silk mask, etc., all of which have the ingredients of natural silk protein (fiber)." Xu Hanfu said that due to its excellent comprehensive performance, natural silk protein has been organized in organizational engineering, biomedicine, and biomedicine,, biomedicine,,, biomedicine,,, biomedicine,,, biomedicine,, The development and application of information technology, food and other fields is very active, and the application scope has been expanded to all aspects of people's lives, such as surgical bone nails, trauma accessories, drugs, nerve catheters, sensors, cosmetics, food plastic wrap, etc. The molecular foundation of high -efficiency silk production and silk traits of the family silkworms has important guiding significance for silk performance transformation, molecular breeding and the diversification of silk protein, and high -value development and utilization. (Finish)

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