The genetic password of the deciphering pharmaceutical plant

Our newspaper Chengdu, July 3rd (Reporter Zhou Hongshuang) Chengdu University of Traditional Chinese Medicine held a press conference on the 2nd to announce the launch of the "Thousands of Moisturizing Genome Plan". The plan is based on the medicinal plant species collected by China, India, the European Union, the United States, Japan, South Korea, Brazil, and Egypt. Sequencing and follow -up research such as genetic functions, genetic breeding and synthetic biology.

Traditional Chinese medicine is the treasure of the Chinese nation. It is a unique health resources in my country, huge potential economic resources, scientific and technological resources with original advantages, excellent cultural resources and important ecological resources. Experts point out that with the development of modern science, our awareness of traditional Chinese medicine has gradually transitioned from early experience accumulation to in -depth research on Chinese medicine in application modern science and technology. It is mainly concentrated in basic applications such as morphological identification, chemical identification, pharmacological analysis and other basic applications Studies, but the understanding of the genetic resources of traditional Chinese medicine plants is still very weak, which will restrict the formation of traditional Chinese medicine plant resources, new varieties of breeding, bio -synthesis of drug -effective ingredients, and the establishment of the pharmaceutical plant model species system.

"The implementation of the grass genome is the only way for the modernization of traditional Chinese medicine." Chen Shilin, chief professor of Chengdu University of Traditional Chinese Medicine, said, the "Thousands of Materia Medica Projects" will interpret the biological mechanism of traditional drugs by obtaining genome and genetic information. Carry out research and development, and promote a series of problems facing solving the study of traditional Chinese medicine, including the establishment of a pharmaceutical model biological system for biological synthesis and regulatory research for secondary metabolic products, natural drugs or new drug raw materials that are important through synthetic biological students,, and new drug raw materials,, and new drug raw materials,, raw materials for the production of biological students. Use genome auxiliary breeding to cultivate excellent varieties of Chinese herbal medicines, develop molecular marks for identifying mixed fakes of Chinese pharmaceutical materials, reveal the nature of pharmaceuticals, and establish precious pharmaceutical genetic resources to protect the grass database.

In 2010, the Chen Shilin research team proposed the "Materia Medica Genome Project" to conduct a whole genome sequencing and post -genius research on medicinal plants with major economic value and typical secondary metabolic channels. A group of high -quality medicinal plant genome sequences such as Su, Chrysanthemum, Coptis chinensis, Danshen, Birch, and Equipment, etc., and formulate operation strategies for the complexity of different genome, which can quickly and efficiently complete batch genome sequencing and data processing work. On this basis, research teams have also achieved remarkable results in research fields such as the analysis of the medicinal channels, the synthetic biology and pharmaceutical plant molecular breeding, etc., and provided a strong manner for the smooth implementation of the "Thousands of Moose Genome Projects". Assure.

Next, the team will complete the assembly of thousands of medicinal plant genome, build an international pharmaceutical plant genome research major science alliance, establish China's leading position in the field of international medicinal plant genome; Research on the synthesis, regulation and transportation of plant effective ingredients; establish a database of thousands of medicinal plant genome to promote the safety of medicinal plant genes as national strategic safety; build thousands of medicinal plant living resource gardens and seed libraries; promote high -quality herbal medicines new Bio -synthesis of variety selection and effective ingredients.

Zhang Boli, an academician of the Chinese Academy of Engineering and Honorary Dean of the Chinese Academy of Traditional Chinese Medicine, said that in the past 50 years, many research results of traditional Chinese medicine have mainly benefited from the development of chemical disciplines, that is, the extraction, separation, appraisal, pharmacological pharmacology, and poison of the effective ingredients of traditional Chinese medicine are studied. Planning, quality control, etc., basically studied the composition of the chemical composition of traditional Chinese medicine. Among them, the iconic results, that is, the team of Tu Yu is separated from Artemisia annua. The "Thousands of Materia Medica Projects" opened another window for the research of Chinese herbal medicine by interpreting the genetic background and biological mechanism of traditional herbal medicines, expanded a new research field and field, and can solve a series of problems faced in Chinese medicine research. Essence

At the press conference, the "Thousands of Materia Medica Projects" Research Alliance was unveiled. Yu Shuguang, president of Chengdu University of Traditional Chinese Medicine, said that under the strong joint of all experts, this plan will not only provide research on the development of new breeding, synthetic biology and endangered pharmaceutical plant protection and relocation protection of medicinal plants. Support will also help the pharmaceutical plants and traditional Chinese medicine fields in depth integration with cutting -edge life science and technology to achieve leapfrog and development in the field of pharmaceutical research.

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